Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

The MET signaling system, autism and gastrointestinal dysfunction  

In this project, researchers will directly investigate relationships between co-occurring gastrointestinal dysfunction (GID) and autism spectrum disorders (ASD), testing a biological hypothesis regarding disruption of the tyrosine kinase receptor MET receptor and its associated intracellular signaling events as a common theme in ASD. Genetic polymorphisms in MET have been implicated in ASD, and MET plays a role in brain wiring and gastrointestinal epithelial cell repair. Researchers will follow a pediatric group with and without ASD, characterizing their GI function and genotyping for sequence alterations in the MET gene to connect the genetic risk findings with biological changes. The studies will provide unique epidemiological descriptions of the study population giving insight into stratification of the ASD subgroup that is characterized by the presence of GID. Identification of biomarkers such as pan-MET and phospho-MET protein levels may also benefit diagnosis and treatment for ASD. Project Status
ONGOING

2010

Funder National Institutes of Health
Fiscal Year Funding $277,299.00
Current Award Period 2009-2011
Project Number 5R21HD065289-02
Principal Investigator Levitt, Pat
Received ARRA Funding? Yes
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Co-occurring Conditions
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SE. Launch three studies that target the underlying biological mechanisms of co-occurring conditions with autism, including seizures/epilepsy, sleep disorders, wandering/elopement behavior, and familial autoimmune disorders, by 2012. IACC Recommended Budget: $9,000,000 over 5 years.
Federal or Private? Federal
Institution University of Southern California
State/Country California
Web Link 1 The MET signaling system, autism and gastrointestinal dysfunction (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects The MET signaling system, autism and gastrointestinal dysfunction | $292,923.00 | 2009 | 1R21HD065289-01