Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Molecular components of A-type K+ channels  

This project investigates the relevance of newly discovered components of ion channels in brain neurons that are important in learning, pain control, and the pathogenesis of epilepsy and autism. Fast transient potassium currents, such as those found in neurons and cardiac cells, are essential for the proper functioning of the brain and the heart. During pathological conditions, abnormalities in these currents can contribute to disease conditions. This project addresses the molecular nature of the ion channels responsible for the generation of these currents in mammalian neurons, using both cellular and mouse models. It seeks to establish the molecular composition of these channels and to elucidate the physiological significance of the identified components. Project Status
ONGOING

2010

Funder National Institutes of Health
Fiscal Year Funding $349,013.00
Current Award Period 2009-2014
Project Number 5R01NS045217-07
Principal Investigator Rudy, Bernardo
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Co-occurring Conditions
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SE. Launch three studies that target the underlying biological mechanisms of co-occurring conditions with autism, including seizures/epilepsy, sleep disorders, wandering/elopement behavior, and familial autoimmune disorders, by 2012. IACC Recommended Budget: $9,000,000 over 5 years.
Federal or Private? Federal
Institution New York University School of Medicine
State/Country New York
Web Link 1 Molecular components of A-type K+ channels (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Molecular components of A-type K+ channels | $352,538.00 | 2009 | 2R01NS045217-06A1