Project Detail
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Office of Autism Research Coordination (OARC) logo

Mechanisms for 5-HTT control of PPI and perseverative behavior using mouse models (supplement)  

Sensorimotor gating is a neural mechanism that filters out extra stimuli and processes information that comes in rapid succession. Prepulse inhibition (PPI) is a form of startle plasticity that provides an operational measure of sensorimotor gating. Sensorimotor gating and PPI may be modulated by serotonin transporters (5-HTT), and deficits in this function are observed in obsessive compulsive disorder (OCD) and autism. Evidence has shown that reducing serotonin transporters leads to improvement in perseverative (repetitive) behaviors. This study will use behavioral and genetic mouse models to identify the neural mechanisms by which serotonin transporters (5-HTT) control sensorimotor gating deficits and repetitive behaviors. This approach could lead to novel animal models of the sensorimotor gating deficits and perseverative behaviors in OCD and autism. Project Status
NEW

2010

Funder National Institutes of Health
Fiscal Year Funding $6,802.00
Current Award Period 2010-2011
Project Number 3R01MH079424-03S2
Principal Investigator Dulawa, Stephanie
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Sensory and Motor Function
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.
Federal or Private? Federal
Institution University of Chicago
State/Country Illinois
Web Link 1 Mechanisms for 5-HTT control of PPI and perseverative behavior using mouse models (supplement) (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Mechanisms for 5-HTT control of PPI and perseverative behavior using mouse models | $345,375.00 | 2009 | 5R01MH079424-03
Mechanisms for 5-HTT control of PPI and perseverative behavior using mouse models | $387,353.00 | 2010 | 5R01MH079424-04
Mechanisms for 5-HTT control of PPI and perseverative behavior using mouse models | $345,375.00 | 2008 | R01MH079424-02