Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Simons Variation in Individual Project (Simons VIP) Core Leader Gift  

The Simons Variation In Individuals Project (Simons VIP) was launched in 2010 to identify and study a large number of individuals (~200 families within two years) with a recurrent genetic variation (deletion or duplication of segment 16p11.2) that increases their risk of developing autism spectrum and other neuro-developmental disorders. The immediate goal is to identify medical, cognitive, neural and behavioral profiles shared by this genetically identified group. Families are recruited through web-based networks or referral by clinical genetic centers or testing laboratories. Extensive psychological and neurological testing and neuroimaging with a uniform protocol will take place at the collaborating medical centers. De-identified subject data and biospecimens will be available to qualified researchers worldwide. Careful analysis of genetically defined autism subtypes will allow detailed phenotypic comparisons within and between these groups to clarify genotype-phenotype correlations. Longer-term goals are to use these data to improve the quality of clinical care and to develop targeted interventions for individuals with autism. Project Status
NEW

2010

Funder Simons Foundation
Fiscal Year Funding $24,730.50
Current Award Period 2010-2012
Project Number 186001
Principal Investigator Hanson, Ellen
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Subcategory Subgroups/Biosignatures
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.
Federal or Private? Private
Institution Children's Hospital Boston
State/Country Massachusetts
Web Link 1 Simons Variation in Individual Project (Simons VIP) Core Leader Gift (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Not available at this time. This functionality is experimental.