Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Gene expression profiling of autism spectrum disorders  

Autism spectrum disorders (ASD) are likely caused by interactions between genetic and environmental factors which result in changes in neural development and activity. Identifying reproducible changes in gene expression levels in individuals with ASD would be a valuable tool, both for understanding the molecular basis of these disorders and in developing earlier and more accurate diagnostic tests. Dr. Collins will examine gene expression profiles in individuals with ASD using microarray technology, a technique used to measure the levels of expression of thousands of genes simultaneously. Gene expression in peripheral blood from ASD patients will be compared to that of healthy controls, and genes expressed at either higher or lower levels in the ASD patients will be identified. This approach may identify novel genes which are misregulated in autism, as well as provide the basis for the development of newer, more sensitive diagnostic tools for this disorder. Project Status
ONGOING

2010

Funder Autism Speaks
Fiscal Year Funding $0.00
Current Award Period 2008-2010
Project Number 4828
Principal Investigator Collins, Christin
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Causes)
Subcategory Genetic Risk Factors
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.
Federal or Private? Private
Institution Children's Hospital Boston
State/Country Massachusetts
Web Link 1 Gene expression profiling of autism spectrum disorders (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Gene expression profiling of autism spectrum disorders | $52,000.00 | 2009 | 4828
Gene expression profiling of autism spectrum disorders | $51,000.00 | 2008 | 4828