Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Investigation of genes involved in synaptic plasticity in Iranian families with ASD  

Autism spectrum disorders (ASD) are thought to involve changes in synaptic plasticity, or the remodeling of neural connections during development. Mutations in genes associated with a particular modulator of synaptic plasticity, the N-methyl-D-aspartate (NMDA) neurotransmitter receptor, have been shown to contribute to mental retardation, fragile X syndrome, and tuberous sclerosis complex, all of which are conditions associated with ASD. These genes might therefore contribute to ASD by disrupting a molecular pathway common to all of these disorders and affecting synaptic plasticity. In this study, six genes involved in NMDA receptor-dependent synaptic plasticity will be examined in a study of Iranian families with ASD. The sequence of these genes will be examined in DNA from related individuals, both typical and with ASD, to determine whether sequence variations in any of these genes are associated with ASD. Project Status
ONGOING

2010

Funder Autism Speaks
Fiscal Year Funding $0.00
Current Award Period 2008-2010
Project Number 2676
Principal Investigator Santangelo, Susan
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Causes)
Subcategory Genetic Risk Factors
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.
Federal or Private? Private
Institution Massachusetts General Hospital
State/Country Massachusetts
Web Link 1 Investigation of genes involved in synaptic plasticity in Iranian families with ASD (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Investigation of genes involved in synaptic plasticity in Iranian families with ASD | $0.00 | 2009 | 2676
Investigation of genes involved in synaptic plasticity in Iranian families with ASD | $60,000.00 | 2008 | 2676