Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

ACE Center: Targeting genetic pathways for brain overgrowth in autism spectrum disorders  

This grant provides support for an NIH Autism Center of Excellence (ACE). This study will investigate the genetic variation of specific pathways that may be responsible for brain overgrowth in autism spectrum disorders. The research is based on the hypothesis that three pathways regulating growth and programmed cell death could be responsible for the observed changes in brain size early in the course of autism: 1) increased activity in the Wnt cell signaling pathway, 2) increased activity of genes important for neurogenesis, and 3) decreased activity of genes important for programmed cell death (apoptosis). Biochemical tests will determine whether genetic variation in these pathways and cell processes exist between typically developing infants, developmentally delayed infants, and infants with autism spectrum disorder. Project Status
ONGOING

2010

Funder National Institutes of Health
Fiscal Year Funding $357,789.00
Current Award Period 2007-2012
Project Number 5P50MH081755-04
Principal Investigator Wynshaw-Boris, Anthony
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Causes)
Subcategory Genetic Risk Factors
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.
Federal or Private? Federal
Institution University of California, San Diego
State/Country California
Web Link 1 ACE Center: Targeting genetic pathways for brain overgrowth in autism spectrum disorders (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects ACE Center: Targeting genetic pathways for brain overgrowth in autism spectrum disorders | $371,478.00 | 2009 | 5P50MH081755-03