Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Finding autism genes by genomic copy number analysis  

Autism is a disorder that is likely caused by the interaction of genetic predispositions and environmental triggers that coalesce during a sensitive period of development to lead to the spectrum of behaviors known as autism spectrum disorder (ASD). In this project, researchers will examine 1) altered gene expression that may permit early identification of affected or at-risk children, 2) gene copy number analyses in ASD biological samples, 3) molecular mechanisms underlying the autism, 4) imaging results from typical and ASD brain during visual face processing, and 5) treatment regimens within the context of altered gene expression or neural function. The investigators in this application also aim to continue their collaborative effort that has produced and enhanced a highly successful open data and biomaterials resource for the research community, the Autism Genetic Resource Exchange (AGRE). This collaborative network application, involving six research sites and AGRE, will systematically and comprehensively investigate the genetics of ASD to identify rare mutations, chromosomal abnormalities, and common variation contributing to ASD susceptibility. Project Status


Funder National Institutes of Health
Fiscal Year Funding $582,867.00
Current Award Period 2007-2012
Project Number 5R01MH083565-04
Principal Investigator Walsh, Christopher
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Causes)
Subcategory Genetic Risk Factors
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3SA. Coordinate and implement the inclusion of approximately 20,000 subjects for genome-wide association studies, as well as a sample of 1,200 for sequencing studies to examine more than 50 candidate genes by 2011. Studies should investigate factors contributing to phenotypic variation across individuals that share an identified genetic variant and stratify subjects according to behavioral, cognitive, and clinical features. IACC Recommended Budget: $43,700,000 over 4 years.
Federal or Private? Federal
Institution Children's Hospital Boston
State/Country Massachusetts
Web Link 1 Finding autism genes by genomic copy number analysis (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Finding autism genes by genomic copy number analysis | $574,507.00 | 2009 | 5R01MH083565-03
Finding autism genes by genomic copy number analysis | $557,773.00 | 2008 | R01MH083565-02