Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

DNA methylation and other epigenetic studies of autism brain  

This study is looking for abnormal gene expression patterns in the brains of individuals with autism. One way that genes are turned off is through DNA methylation: an enzyme places a methyl group onto certain sequences of DNA, thus flagging those genes for silencing. Thus, by examining the methylation status of genes, one can tell whether the gene is turned off or not. Researchers will examine the methylation patterns of genes taken from post-mortem brain tissue of autistic individuals and compare them to tissue from controls. The primary tool for analysis will be DNA microarrays ("gene chips"), which allow a genome-wide scan. Project Status
ONGOING

2010

Funder Autism Speaks
Fiscal Year Funding $43,986.00
Current Award Period 2008-2010
Project Number 2230
Principal Investigator Beaudet, Arthur
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Causes)
Subcategory Epigenetics
Strategic Plan Objective New! Green dot: Objective has greater than or equal to the recommended funding. 3SJ. Support at least three studies that focus on the role of epigenetics in the etiology of ASD, including studies that include assays to measure DNA methylations and histone modifications and those exploring how exposures may act on maternal or paternal genomes via epigenetic mechanisms to alter gene expression, by 2012. IACC Recommended Budget: $20,000,000 over 5 years.
Federal or Private? Private
Institution Baylor College of Medicine
State/Country Texas
Web Link 1 DNA methylation and other epigenetic studies of autism brain (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects DNA methylation and other epigenetic studies of autism brain | $0.00 | 2009 | 2230
DNA methylation and other epigenetic studies of autism brain | $29,000.00 | 2008 | 2230