Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Design & synthesis of novel CNS-active oxytocin and vasopressin receptor ligands  

Receptors for vasopressin and oxytocin peptides are found in several parts of the body, including the central nervous system (CNS). Vasopressin and oxytocin have been shown to have profound effects in animal models of social behavior. These models are being used to understand human social deficit disorders such as the symptoms seen in the pervasive development disorders (PDD). However, a lack of CNS selective ligands has hindered progress in the area of neurological disorders. This study will develop small, drug-like agonists for the oxytocin and vasopressin receptors that are selective and able to cross the blood-brain barrier and will test them in models of social behavior. Lead compounds will be identified for further drug development as potential therapeutic treatment in PDD. Project Status
ONGOING

2010

Funder National Institutes of Health
Fiscal Year Funding $560,535.00
Current Award Period 2009-2012
Project Number 5R01MH082878-02
Principal Investigator Roberts, Edward
Received ARRA Funding? Yes
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Treatments)
Subcategory Model Systems/Therapeutic Targets
Strategic Plan Objective 4O. Not specific to Question 4 objectives
Federal or Private? Federal
Institution The Scripps Research Institute
State/Country California
Web Link 1 Design & synthesis of novel CNS-active oxytocin and vasopressin receptor ligands (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Design & synthesis of novel CNS-active oxytocin and vasopressin receptor ligands | $584,206.00 | 2009 | 1R01MH082878-01A1