Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Treatment of sleep problems in children with autism spectrum disorder with melatonin: A double-blind, placebo-controlled study  

This study will examine whether sleep problems in children with autism spectrum disorder (ASD) are related to alterations in the production of melatonin (MT), a hormone that plays an important role in regulating the sleep-wake cycle. This study will also examine whether MT is effective in improving sleep in children with ASD. The two hypotheses that will be tested are: 1) Children with ASD and sleep problems will have a delayed sleep-wake cycle and/or decreased MT production compared with those without sleep problems; and 2) treatment with MT will be associated with improved sleep and behavior. Sleep disturbance will be measured using a standardized questionnaire. The MT levels will be measured in saliva in two groups of children with ASD both with and without sleep problems. Total 24-hour MT production will be determined from urine samples in these same two groups. Eligible participants will then be enrolled in a trial of three oral doses of MT (3, 6, 9 mg) and a placebo. Project Status
ONGOING

2010

Funder Autism Speaks
Fiscal Year Funding $127,500.00
Current Award Period 2007-2011
Project Number 2003
Principal Investigator Hopkins, Bobbi
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Treatments)
Subcategory Medical/Pharmacologic
Strategic Plan Objective Yellow dot: Objective has some degree of funding, but less than the recommended amount. 4SA. Support at least three randomized controlled trials that address co-occurring medical conditions associated with ASD by 2010. IACC Recommended Budget: $13,400,000 over 3 years.
Federal or Private? Private
Institution Baylor College of Medicine
State/Country Texas
Web Link 1 Treatment of sleep problems in children with autism spectrum disorder with melatonin: A double-blind, placebo-controlled study (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Treatment of sleep problems in children with autism spectrum disorder with melatonin: A double-blind, placebo-controlled study | $8,775.00 | 2010 | 5M01RR000188-46
Treatment of sleep problems in children with autism spectrum disorder with melatonin: A double-blind, placebo-controlled study | $150,000.00 | 2009 | 2003
Treatment of sleep problems in children with autism spectrum disorder with melatonin: A double-blind, placebo-controlled study | $6,814.00 | 2009 | 5M01RR000188-45
Treatment of sleep problems in children with autism spectrum disorder with melatonin: A double-blind, placebo-controlled study | $150,000.00 | 2008 | 2203