Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Evaluation of altered fatty acid metabolism via gas chromatography/mass spectroscopy and time-of-flight secondary ion mass spectroscopy imaging in the propionic acid rat model of autism spectrum disorders  

Researchers hypothesize that propionic acid (PPA) and related enteric short chain fatty acids are likely molecular candidates linking the disparate dietary, gastrointestinal, neuropatholigcal, behavioral, metabolic, and metabolic disturbances seen in autism. In this study, live rat exposure to propionate and other short-chain fatty acids will be followed by an animal-model demonstration and organ analysis. The brains and tissues of the rats will be analyzed with Time of Flight (ToF)-SIMS imaging, which will enable rapid anatomical determination of key biomarkers in ASD pathology and relate these markers to available human samples such as gut or blood. These animal studies will provide further evidence that behavioral, neuropathological, electrophysiological, and biochemical abnormalities with PPA exposure can be reduced by treatment (such as diet, costridial eradication, probiotics, etc.), which are our long term goals. Project Status
NEW

2010

Funder Autism Research Institute
Fiscal Year Funding $25,000.00
Current Award Period 2010
Project Number 2010-2
Principal Investigator MacFabe, Derrick
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Treatments)
Subcategory Model Systems/Therapeutic Targets
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Private
Institution University of Western Ontario
State/Country Canada
Web Link 1 Evaluation of altered fatty acid metabolism via gas chromatography/mass spectroscopy and time-of-flight secondary ion mass spectroscopy imaging in the propionic acid rat model of autism spectrum disorders (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
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