Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

The role of SHANK3 in the etiology of autism spectrum disorder  

Mutations in the SHANK3 gene have been implicated in a subset of patients with autism spectrum disorder (ASD) in a gene-dosage dependent manner. SHANK3, a putative scaffold molecule found at the post-synaptic density (PSD), binds multiple partners and has been termed the master scaffolding molecule of the PSD. One of the key interactors of SHANK3 is the Homer class of signaling and scaffold molecules. SHANK3 and Homer act in concert to regulate spine maturation. The study describes a novel Homer-dependent mechanism to stabilize SHANK3 at the PSD. Both genetic and pharmacological tools can modulate this pathway, thus having implications for ASD therapy. Finally, the study is making a novel mouse model of SHANK3 that mimics a reported deletion of the Homer-binding domain of SHANK3 in patients with ASD. This mouse model will be a useful tool to study the in vivo function of SHANK3. The study makes predictions on the stability of SHANK3 in this mouse model and proposes a repertoire of biochemical and behavioral tests to link its molecular model with ASD-like behavior. Project Status
ONGOING

2010

Funder Autism Speaks
Fiscal Year Funding $28,000.00
Current Award Period 2009-2011
Project Number 6313
Principal Investigator Bangash, M. Ali
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Treatments)
Subcategory Model Systems/Therapeutic Targets
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Private
Institution Johns Hopkins University
State/Country Maryland
Web Link 1 The role of SHANK3 in the etiology of autism spectrum disorder (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
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