Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Deriving neuroprogenitor cells from peripheral blood of individuals with autism  

Being able to obtain tissue from autistic patients in a noninvasive manner would enhance the ability of researchers to study the cellular changes which occur in autistic brains. A potential technique to circumvent this problem is the use of peripheral mononuclear blood cells (or PMBCs), which are similar to stem cells and can be obtained from blood samples. In the laboratory, PMBCs can be differentiated into multiple types of cells, including neurons. In this study, Dr. Fujinami and colleagues will test the feasibility of making neurons from PMBCs obtained from autistic individuals. If neurons can be derived from these cells, they will examine the characteristics of the neurons obtained from autistic individuals to determine whether they differ from those derived from typical individuals. Neurons from autistic individuals, for example, might express different genes than those from typical individuals or survive at different rates. This research could provide a powerful new tool to study neuronal function in autism and supplement the data obtained from traditional postmortem analyses. Project Status
ONGOING

2010

Funder Autism Speaks
Fiscal Year Funding $0.00
Current Award Period 2008-2010
Project Number 2728
Principal Investigator Fujinami, Robert
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Treatments)
Subcategory Model Systems/Therapeutic Targets
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Private
Institution University of Utah
State/Country Utah
Web Link 1 Deriving neuroprogenitor cells from peripheral blood of individuals with autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Deriving neuroprogenitor cells from peripheral blood of individuals with autism | $46,596.85 | 2009 | 2728
Deriving neuroprogenitor cells from peripheral blood of individuals with autism | $60,000.00 | 2008 | 2728