Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Neuropharmacology of motivation and reinforcement in mouse models of autistic spectrum disorders  

In this study, mouse models of autism spectrum disorders will be used to investigate the effects of drug treatment on motivated behaviors. To model behavioral therapy in mice, intracranial electrical stimulation (ICSS) will be used. ICSS measures motivated behaviors: an electrode implanted in a specific region of a mouse's brain provides a "reward" sensation when a lever is pressed. Animals will self-stimulate by pressing the lever, and the administration of drugs known to affect the reward pathway can modulate this response. In this study, researchers will use ICSS to study motivated behaviors in three commonly used mouse models of autism (fragile X syndrome, Rett syndrome, and Angelman syndrome). These mice will be treated with drugs which are known to affect reward pathways and drugs which are commonly used to treat autism, such as dopamine-blocking neuroleptics. These experiments will determine whether these drugs enhance or impair motivated behaviors in animals with autistic behaviors. Project Status
ONGOING

2010

Funder Autism Speaks
Fiscal Year Funding $0.00
Current Award Period 2008-2011
Project Number 2670
Principal Investigator Malanga, C.J.
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Treatments)
Subcategory Model Systems/Therapeutic Targets
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Private
Institution University of North Carolina School of Medicine
State/Country North Carolina
Web Link 1 Neuropharmacology of motivation and reinforcement in mouse models of autistic spectrum disorders (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Neuropharmacology of motivation and reinforcement in mouse models of autistic spectrum disorders | $0.00 | 2009 | 2670
Neuropharmacology of motivation and reinforcement in mouse models of autistic spectrum disorders | $150,000.00 | 2008 | 2670