Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Mouse genetic model of a dysregulated serotonin transporter variant associated with autism  

Elevated serotonin levels are frequently found to be associated with autism. Serotonin levels may be regulated by the serotonin transporter (encoded by the SERT gene), which is responsible for transporting serotonin to the inside of cells. A rare mutation in the SERT gene has been previously identified in several autistic individuals. While many mutations inactivate genes, this particular mutation seems to increase rather than decrease the activity of the serotonin transporter. To examine the functional and behavioral consequences of this mutation in the SERT gene, the present study will engineer mice to carry the mutation. This study will focus on behavioral analyses to determine whether the mutation found in humans will cause autistic-like behaviors in a mouse model. These behavioral analyses will provide a basis for the future exploration of the molecular basis of autistic behaviors related to the serotonin transporter. Project Status
ONGOING

2010

Funder Autism Speaks
Fiscal Year Funding $0.00
Current Award Period 2008-2010
Project Number 2429
Principal Investigator Veenstra-Vanderweele, Jeremy
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Treatments)
Subcategory Model Systems/Therapeutic Targets
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Private
Institution Vanderbilt University
State/Country Tennessee
Web Link 1 Mouse genetic model of a dysregulated serotonin transporter variant associated with autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Mouse genetic model of a dysregulated serotonin transporter variant associated with autism | $60,000.00 | 2009 | 2429
Mouse genetic model of a dysregulated serotonin transporter variant associated with autism | $60,000.00 | 2008 | 2429