Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Synaptic plasticity, memory and social behavior  

This is an individual National Research Service Award for post-doctoral research training, which provides support for promising Fellowship Applicants with the potential to become productive, independent investigators in scientific health-related research fields. This proposal is focused on studying the signaling pathways that regulate translation in a mouse model of tuberous sclerosis complex (TSC). The hypothesis is that inhibition of the TSC1/TSC2 protein complex will result in alterations in hippocampal synaptic plasticity, hippocampus-dependent memory, and social behavior via upregulated signaling in the mTOR pathway. Electrophysiological, behavioral, and biochemical analyses will be used to determine whether protein synthesis-dependent synaptic plasticity and mTOR signaling are altered in images of hippocampal brain slices, as well as whether these mice are impaired in hippocampus-dependent learning and memory and social interaction. These studies are among the few to examine the dysfunction of molecular signaling that controls translation and whether they are correlated with altered synaptic plasticity and behavior that would be consistent with autism and mental retardation. Project Status
ONGOING

2010

Funder National Institutes of Health
Fiscal Year Funding $52,154.00
Current Award Period 2009-2011
Project Number 5F32MH085489-02
Principal Investigator Chevere-Torres, Itzamarie
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Treatments)
Subcategory Model Systems/Therapeutic Targets
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Federal
Institution New York University
State/Country New York
Web Link 1 Synaptic plasticity, memory and social behavior (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Synaptic plasticity, memory and social behavior | $50,054.00 | 2009 | 1F32MH085489-01A1