This is an individual National Research Service Award for post-doctoral research training, which provides support for promising Fellowship Applicants with the potential to become productive, independent investigators in scientific health-related research fields. This proposal is focused on studying the signaling pathways that regulate translation in a mouse model of tuberous sclerosis complex (TSC). The hypothesis is that inhibition of the TSC1/TSC2 protein complex will result in alterations in hippocampal synaptic plasticity, hippocampus-dependent memory, and social behavior via upregulated signaling in the mTOR pathway. Electrophysiological, behavioral, and biochemical analyses will be used to determine whether protein synthesis-dependent synaptic plasticity and mTOR signaling are altered in images of hippocampal brain slices, as well as whether these mice are impaired in hippocampus-dependent learning and memory and social interaction. These studies are among the few to examine the dysfunction of molecular signaling that controls translation and whether they are correlated with altered synaptic plasticity and behavior that would be consistent with autism and mental retardation.