Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Serotonin, autism, and investigating cell types for CNS disorders  

This is an NIH Pathway to Independence Award, which provides an opportunity for promising postdoctoral scientists to receive both mentored and independent research support from the same award. For many disorders, including autism, the circuits and cells underlying the disease are unknown. The researcher will use a powerful genetic approach, called Translating Ribosome Affinity Purification (TRAP), to identify the complete suite of genes being employed by cells isolated from autism patients. In previous studies using autism patient cells, the TRAP methodology uncovered specific mutations in genes involved in the serotonin pathway. The current proposal seeks to confirm these findings in independent samples, and then to recapitulate this genetic mutation in a mouse to test for features of autism. Even if patients have a variety of different underlying genetic causes for a disease, one common cellular mechanism could provide a valuable target for treatment strategies. The approach proposed here may have the potential to provide those cellular targets for treatments. Project Status
ONGOING

2010

Funder National Institutes of Health
Fiscal Year Funding $90,000.00
Current Award Period 2009-2011
Project Number 5K99NS067239-02
Principal Investigator Dougherty, Joseph
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Treatments)
Subcategory Model Systems/Therapeutic Targets
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Federal
Institution The Rockefeller University
State/Country New York
Web Link 1 Serotonin, autism, and investigating cell types for CNS disorders (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Serotonin, autism, and investigating cell types for CNS disorders | $90,000.00 | 2009 | 1K99NS067239-01