Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Exploring the neuronal phenotype of autism spectrum disorders using induced pluripotent stem cells  

Autism is considered to be among the most common of the serious developmental disabilities, second only to mental retardation. The lifetime per capita incremental societal cost is estimated at $3.2 million. Because the deficits in autism affect human-specific social behaviors, the mechanisms underlying autism will need to be studied in human patients and in cells. The goal of this project is to develop the methods to convert skin cells from patients with autism into neurons and to characterize these neurons using high content screens. These experiments will allow researchers to study the neurons of individuals diagnosed with autism and will lead to a better understanding of the development and differentiation of neurons. Project Status
ONGOING

2010

Funder National Institutes of Health
Fiscal Year Funding $241,503.00
Current Award Period 2009-2011
Project Number 5R21MH087898-02
Principal Investigator Hallmayer, Joachim; Dolmetsch, Ricardo
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Treatments)
Subcategory Model Systems/Therapeutic Targets
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Federal
Institution Stanford University
State/Country California
Web Link 1 Exploring the neuronal phenotype of autism spectrum disorders using induced pluripotent stem cells (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Exploring the neuronal phenotype of autism spectrum disorders using induced pluripotent stem cells | $258,420.00 | 2009 | 1R21MH087898-01