Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Autism iPSCs for studying function and dysfunction in human neural development  

Autism is a disorder of neural development whose causes are virtually unknown; largely because of this lack of knowledge, there are no consistently successful treatments for this disease. The goal of this project is to shed light on the causes of autism by studying development of the nervous system in a controlled tissue culture environment using sophisticated molecular tools. Cells from the skin of autistic patients will be obtained, using a virtually painless procedure, and then turned into induced pluripotent stem cells (iPSCs) that can develop into every cell type in the body. The development of these cells into nerve cells will be studied in tissue culture, comparing them with cells from unaffected children. This study should help elucidate what goes wrong during brain development in autistic children and help develop a strategy for effective treatment. Project Status
ONGOING

2010

Funder National Institutes of Health
Fiscal Year Funding $254,152.00
Current Award Period 2009-2011
Project Number 5R21MH087925-02
Principal Investigator Loring, Jeanne
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Treatments)
Subcategory Model Systems/Therapeutic Targets
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Federal
Institution The Scripps Research Institute
State/Country California
Web Link 1 Autism iPSCs for studying function and dysfunction in human neural development (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Autism iPSCs for studying function and dysfunction in human neural development | $317,520.00 | 2009 | 1R21MH087925-01