Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Role of L-type calcium channels in hippocampal neuronal network activity  

This is an individual National Research Service Award for pre-doctoral research training, which provides support for promising doctoral candidates who will be performing dissertation research and training in a scientific health-related field. Autism spectrum disorder (ASD) is a pervasive but poorly understood neurological disorder. Timothy Syndrome, a disorder with a highly significant link to ASD, has recently been shown to originate from one gene with a single nucleotide substitution within the L-type calcium channel. This mutation prolongs channel opening, an effect that can be mimicked pharmacologically by the drug BayK 8644. This allows recapitulation of TS in an animal model to generate findings that can potentially generalize to other ASDs. This mouse model will allow for a detailed investigation of TS from molecular mechanisms to hippocampal circuitry. The goal of this proposal is to characterize the effects of BayK 8644 on physiological processes in the hippocampus at multiple levels from synapses to circuits and to provide a roadmap for how a single molecular malfunction can affect the functioning of a neural circuit leading to a disease phenotype. Project Status
ONGOING

2010

Funder National Institutes of Health
Fiscal Year Funding $32,741.00
Current Award Period 2008-2011
Project Number 5F31MH084430-03
Principal Investigator Owen, Scott
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Treatments)
Subcategory Model Systems/Therapeutic Targets
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Federal
Institution Stanford University
State/Country California
Web Link 1 Role of L-type calcium channels in hippocampal neuronal network activity (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Role of L-type calcium channels in hippocampal neuronal network activity | $32,191.00 | 2009 | 5F31MH084430-02
Role of L-type calcium channels in hippocampal neuronal network activity | $34,686.00 | 2008 | F31MH084430-01