Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

High-resolution diffusion tensor imaging in mouse models relevant to autism  

Structural and functional imaging studies have significantly improved the understanding of the neural basis of developmental and neurological disorders. However, despite recent advancements, anatomical imaging in autistic patients has generally revealed little evidence of pathology. In this proposal, high-resolution diffusion tensor imaging (DTI) of the mouse brain will be developed as a surrogate for better diagnosis of autism. The researchers will study the DTI properties of two mouse models that exhibit multiple behavioral and brain phenotypes relevant to autism, including reduced sociability and underdevelopment of the corpus callosum, which is the band of nerve fibers that join the two hemispheres of the brain. While DTI has been used extensively in human subjects, it would be useful to develop this methodology for rodents to assess the relationship between brain structure and social behavioral abnormalities in mouse models relevant to autism. Successful implementation of the proposed DTI techniques in these models will not only be helpful in understanding the biological and physiological basis of autism spectrum disorders, but will also benefit studies of other mouse models of developmental and psychiatric brain disorders. Project Status


Funder National Institutes of Health
Fiscal Year Funding $199,724.00
Current Award Period 2009-2011
Project Number 5R21HD058237-02
Principal Investigator Poptani, Harish
Received ARRA Funding? Yes
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Treatments)
Subcategory Model Systems/Therapeutic Targets
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Federal
Institution University of Pennsylvania
State/Country Pennsylvania
Web Link 1 High-resolution diffusion tensor imaging in mouse models relevant to autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects High-resolution diffusion tensor imaging in mouse models relevant to autism | $253,735.00 | 2009 | 1R21HD058237-01A2