Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Neuroligin function in vivo: Implications for autism and mental retardation  

Autism spectrum disorder and mental retardation are common, debilitating disorders involving social interaction or cognitive function with clinical overlap in a subset of patients. Recently, loss-of-function mutations in members of the Neuroligin family of trans-synaptic cell adhesion molecules have been implicated in human autism and mental retardation. Mice with genetic alterations of Neuroligin will be electrophysiologically and behaviorally characterized as potential animal models of autism and mental retardation in an effort to better understand the cause and treatment of these debilitating disorders. Project Status
ONGOING

2010

Funder National Institutes of Health
Fiscal Year Funding $392,500.00
Current Award Period 2008-2013
Project Number 5R01MH081164-02
Principal Investigator Powell, Craig
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Treatments)
Subcategory Model Systems/Therapeutic Targets
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Federal
Institution University of Texas Southwestern Medical Center
State/Country Texas
Web Link 1 Neuroligin function in vivo: Implications for autism and mental retardation (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Neuroligin function in vivo: Implications for autism and mental retardation | $392,500.00 | 2009 | 1R01MH081164-01A2