Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Cellular and genetic correlates of increased head size in autism spectrum disorder  

Using cells obtained through a skin biopsy, this project will develop lines of induced pluripotent stem cells (iPSC) from typically developing children and children with autism spectrum disorders (ASD) who have exhibited a significant increase in head size compared to typically developing children. These iPSCs will be differentiated into neuronal cells, allowing, for the first time, investigation into differences in the neural cells' proliferation, differentiation, and survival in patients and controls. These differences will be correlated with underlying changes in gene expression and in the genomic sequence. The analysis of gene expression and regulation in neural cells that pertain to individual patients and their clinical phenotype may offer unique insights into disease pathogenesis. Project Status
ONGOING

2010

Funder National Institutes of Health
Fiscal Year Funding $282,901.00
Current Award Period 2009-2011
Project Number 5R21MH087879-02
Principal Investigator Vaccarino, Flora
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Treatments)
Subcategory Model Systems/Therapeutic Targets
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Federal
Institution Yale University
State/Country Connecticut
Web Link 1 Cellular and genetic correlates of increased head size in autism spectrum disorder (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Cellular and genetic correlates of increased head size in autism spectrum disorder | $203,943.00 | 2009 | 1R21MH087879-01