Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Improving synchronization and functional connectivity in autism spectrum disorders through plasticity-induced rehabilitation training  

Electroencephalography (EEG) and magnetic resonance imaging (MRI) have been used extensively to characterize functional and anatomical brain abnormalities associated with Autism Spectrum Disorders (ASD). While the proposed project will contribute to this endeavor, it derives its primary significance from the application of these techniques to intervention. It is generally accepted that autism research should be translational. However, despite solid evidence for the importance of genetic factors in ASD, numerous large-scale genetic studies have failed to translate into effective therapies. The reasons are varied and imply that a comprehensive model of neurodevelopmental disturbances in ASD may not be available for years. However, children with ASD and their parents cannot wait, but rely on the immediate pursuit of treatment options that are promising. This project offers that possibility because it is based on convergent evidence of mirror neuron system involvement in ASD as well as direct evidence suggesting that plasticity-induced rehabilitation training, a type of operant conditioning, may be effective. This promises to produce a substantial impact on the field and possibly to establish this type of intervention broadly as a treatment option. Project Status
ONGOING

2010

Funder Department of Defense
Fiscal Year Funding $0.00
Current Award Period 2010-2012
Project Number AR093335
Principal Investigator Pineda, Jaime
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Treatments)
Subcategory Behavioral
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SF. Launch five randomized controlled trials of interventions including biological signatures and other measures to predict response, and monitor quality of life and functional outcomes, in each of the following groups:
  • Five trials in infants and toddlers by 2013. IACC Recommended Budget: $30,000,000 over 5 years.
  • Three randomized controlled trials of interventions for school-aged children and/or adolescents by 2013. IACC Recommended Budget: $18,000,000 over 5 years.
  • Three trials for adults by 2014. IACC Recommended Budget: $18,000,000 over 5 years.
Federal or Private? Federal
Institution University of California, San Diego
State/Country California
Web Link 1 Improving synchronization and functional connectivity in autism spectrum disorders through plasticity-induced rehabilitation training (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Improving synchronization and functional connectivity in autism spectrum disorders through plasticity-induced rehabilitation training | $487,384.00 | 2009 | AR093335