This grant provides support for an NIH Autism Center of Excellence (ACE). This Core resource will support five interrelated projects that are part of the University of Washington ACE. The UW ACE theme centers on a comprehensive developmental model of risk, risk processes, symptom emergence, and adaptation in autism spectrum disorder (ASD). The proposed studies bring together strong expertise by UW investigators in early intervention, infant social cognition and prelinguistic development, child clinical and developmental psychology, child psychiatry, developmental cognitive neuroscience and neurophysiology, magnetic resonance imaging and spectroscopy, and quantitative approaches to genetic research. This combined expertise has led to projects aimed at discovering both etiologic pathways and effective treatments for autism spectrum disorder.