Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Metabolic biomarkers of autism: Predictive potential and genetic susceptibility  

Based on these researchers' recent discovery that children with autism exhibit abnormal methionine and glutathione metabolism, this project aims to identify if metabolic imbalance results in increased oxidative stress and impaired methylation capacity that may contribute, in part, to the development and clinical manifestations of autism. The researchers will also study if an abnormal metabolic profile is associated with increased frequency of genetic polymorphisms that functionally affect methionine and glutathione metabolism.

2008

Funder National Institutes of Health
Fiscal Year Funding $369,495.00
Project Number R01HD051873-03
Principal Investigator James, Sandra
Strategic Plan Question Question 1: When Should I Be Concerned? (Diagnosis)
Strategic Plan Objective Yellow dot: Objective has some degree of funding, but less than the recommended amount. 1.3 Identify a panel of biomarkers that separately, or in combination with behavioral measures, accurately identify, before age 2, one or more subtypes of children at risk for developing ASD by 2014. IACC Recommended Budget: $33,300,000 over 5 years.
Federal or Private? Federal
Institution Arkansas Children's Hospital Research Institute
State/Country Arkansas
Web Link 1 No URL available.
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Metabolic biomarkers of autism: Predictive potential and genetic susceptibility | $351,076.00 | 2010 | 5R01HD051873-05
Metabolic biomarkers of autism: Predictive potential and genetic susceptibility | $380,150.00 | 2009 | 5R01HD051873-04