Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

A comprehensive approach to identification of autism susceptibility genes  

The proposed study will address the possible role in autism of exposures during the peri-conceptional, gestational, perinatal, and early childhood periods, including infections, assisted reproductive technology, medications, pesticides, brominated flame retardants, and metals. It will also evaluate these environmental factors in conjunction with genes involved in xenobiotic metabolism or suggested by microarray results or by single nucleotide polymorphism (SNP) arrays. Finally, because autism manifests in heterogeneous phenotypes, researchers will examine all exposures in relation to specific subtypes of autism defined by developmental patterns such as regression versus early onset, high versus low adaptive/cognitive function, and by immunologic profiles.

2008

Funder National Institutes of Health
Fiscal Year Funding $3,031,776.00
Project Number R01MH081754-01
Principal Investigator Geschwind, Daniel
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3.4 Initiate efforts to expand existing large case-control and other studies to enhance capabilities for targeted gene – environment research by 2011. IACC Recommended Budget: $27,800,000 over 5 years.
Federal or Private? Federal
Institution University of California, Los Angeles
State/Country California
Web Link 1 No URL available.
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects ACE Network: A comprehensive approach to identification of autism susceptibility genes | $2,823,814.00 | 2010 | 5R01MH081754-03
ACE Network: A comprehensive approach to identification of autism susceptibility genes | $2,895,517.00 | 2009 | 5R01MH081754-02