Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

A molecular genetic study of autism and related phenotypes in extended pedigrees  

Encouraged by reports of a high heritability and a sibling risk ratio > 50, a substantial number of linkage and positional cloning studies have now been conducted. This study proposes a strategy using multigenerational, extended pedigrees with multiple individuals affected with autism, as well as milder but qualitatively similar, genetically-related phenotypes (endophenotypes) in non-autistic relatives. Researchers propose a detailed phenotypic study (including measurement of quantitative and qualitative neuropsychological and behavioral characteristics in autistic individuals and their non-autistic relatives) of twelve of these pedigrees as part of a whole genome linkage study of autism and related phenotypes.

2008

Funder National Institutes of Health
Fiscal Year Funding $582,147.00
Project Number R01MH076028-03
Principal Investigator Piven, Joseph
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3.8 Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.
Federal or Private? Federal
Institution University of North Carolina at Chapel Hill
State/Country North Carolina
Web Link 1 No URL available.
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects A molecular genetic study of autism and related phenotypes in extended pedigrees | $483,824.00 | 2009 | 5R01MH076028-04
A molecular genetic study of autism and related phenotypes in extended pedigrees | $582,231.00 | 2010 | 5R01MH076028-05
A molecular genetic study of autism and related phenotypes in extended pedigrees (supplement) | $99,600.00 | 2010 | 3R01MH076028-04S1