Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Early pharmacotherapy guided by biomarkers in autism  

The investigators have previously shown a different time course in the developmental values of brain serotonin synthesis in children with autism using positron emission tomography (PET). These data are consistent with the notion that serotonin synthesis is abnormal during critical periods of brain development in autistic children. Specific to this project, the investigators demonstrated that serotonin synthesis capacity in children less than the age of six years showed significantly lower values than non-autistic children. Since serotonin is known to be an important factor involved in postnatal synaptogenesis, they hypothesized that one approach to the treatment of autism pharmacologically is the use of serotonin agonists in children less than the age of six years. The goal of this treatment is to provide a more normal serotonergic modulation of synaptic plasticity in autistic children during the early childhood years.

2008

Funder National Institutes of Health
Fiscal Year Funding $1,199,999.00
Project Number U01NS061264-01
Principal Investigator Chugani, Diane
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Interventions)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4.4 Launch three randomized controlled trials of interventions for school-aged and/or adolescents by 2012. IACC Recommended Budget: $15,600,000 over 5 years.
Federal or Private? Federal
Institution Wayne State University
State/Country Michigan
Web Link 1 No URL available.
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects ACE Network: Early pharmacotherapy guided by biomarkers in autism | $1,000,000.00 | 2010 | 5U01NS061264-03
ACE Network: Early pharmacotherapy guided by biomarkers in autism | $100,000.00 | 2009 | 5U01NS061264-02