Project Detail
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Mouse models of the neuropathology of Tuberous Sclerosis Complex  

The goal of this research project is to use mouse genetics to understand the developmental abnormalities that lead to the brain lesions of the genetic disease tuberous sclerosis complex (TSC). These lesions are associated with seizures, autism, and other developmental disabilities. Well-characterized models will establish a foundation for the testing of future targeted therapies and establish developmental neurobiologic differences between subsets of patients with TSC.


Funder National Institutes of Health
Fiscal Year Funding $258,136.00
Project Number R01NS060804-02
Principal Investigator Gambello, Michael
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution University of Texas Health Science Center at Houston
State/Country Texas
Web Link 1 No URL available.
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Mouse models of the neuropathology of tuberous sclerosis complex | $258,344.00 | 2009 | 5R01NS060804-03