Strategic Plan Question Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Question 2: How Can I Understand What Is Happening? (Biology)  

$91,260,348.78
Fiscal Year: 2010

Download 2010 Question 2 projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Modulation of fxr1 splicing as a treatment strategy for autism in fragile X syndrome Lin, Michael Q2.S.D Stanford University
Role of intracellular mGluR5 in fragile X syndrome and autism O'Malley, Karen Q2.S.D Washington University in St. Louis
L-type calcium channel regulation of neuronal differentiation Panagiotakos, Georgia Q2.S.D Stanford University
Angelman syndrome (AS) Percy, Alan Q2.S.D University of Alabama at Birmingham
MeCP2 modulation of BDNF signaling: Shared mechanisms of Rett and autism Pozzo-Miller, Lucas Q2.S.D University of Alabama at Birmingham
Sex differences in early brain development; Brain development in Turner syndrome Santelli, Rebecca Q2.S.D University of North Carolina at Chapel Hill
New approaches to local translation: SpaceSTAMP of proteins synthesized in axons Segal, Rosalind Q2.S.D Dana-Farber Cancer Institute
Regulation of synapse elimination by FMRP Wilkerson, Julia Q2.S.D University of Texas Southwestern Medical Center
Olfactory abnormalities in the modeling of Rett syndrome Ronnett, Gabriele Q2.S.D Johns Hopkins University
Visual system connectivity in a high-risk model of autism Sahin, Mustafa Q2.S.D Children's Hospital Boston
Investigation of postnatal drug intervention's potential in rescuing the symptoms of fragile X syndrome in adult mice Sidorov, Michael Q2.S.D Massachusetts Institute of Technology
Aberrant synaptic function caused by TSC mutation in autism Sulzer, David Q2.S.D Columbia University
Aberrant synaptic form and function due to TSC-mTOR-related mutation in autism spectrum disorders Sulzer, David Q2.S.D Columbia University
TrkB agonist(s), a potential therapy for autism spectrum disorders Sun, Yi Q2.S.D University of California, Los Angeles
Presynaptic fragile X proteins Akins, Michael Q2.S.D Brown University
In-vivo imaging of neuronal structure and function in a reversible mouse model for autism. Ash, Ryan Q2.S.D Baylor College of Medicine
Probing a monogenic form of autism from molecules to behavior Tsien, Richard Q2.S.D Stanford University
Gene silencing in fragile X syndrome Usdin, Karen Q2.S.D National Institutes of Health
The role of the autism-associated gene tuberous sclerosis complex 2 (TSC2) in presynaptic development Williams, Megan Q2.S.D University of California, San Diego
Neural circuit deficits in animal models of Rett syndrome Xiong, Qiaojie Q2.S.D Cold Spring Harbor Laboratory
Functional circuit disorders of sensory cortex in ASD and RTT Carlson, Gregory Q2.S.D University of Pennsylvania
Elucidating the roles of SHANK3 and FXR in the autism interactome Zoghbi, Huda Q2.S.D Baylor College of Medicine
Elucidation and rescue of amygdala abnormalities in the Fmr1 mutant mouse model of fragile X syndrome Corbin, Joshua Q2.S.D George Washington University
Synaptic phenotype, development, and plasticity in the fragile X mouse Cox, Charles Q2.S.D University of Illinois at Urbana Champaign
The functional link between DISC1 and neuroligins: Two genetic factors in the etiology of autism DiDonato, Christine Q2.S.D Children's Memorial Hospital, Chicago