Subcategory Detail
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Office of Autism Research Coordination (OARC) logo

Immune/Metabolic Pathways$5,385,744.28
Fiscal Year: 2010
  

Download 2010 Immune/Metabolic Pathways projects (EXCEL)
These projects focus on understanding the biological mechanisms of metabolism and the immune system that may be altered in autism, typically in cells and animal models. This largely includes studies on inflammation and inflammatory molecules (i.e., cytokines), as well as on the role of mitochondria, energy metabolism, and oxidative stress. Also included in this group are projects seeking to identify specific immune and metabolic triggers in early prenatal and post-natal life, such as maternal infection, maternal auto-antibodies, and toxic exposures.
Graph: Question 2 encompassed a broad range of biological research, resulting in the need to create a larger number of subcategories to adequately describe the breadth of research than was required for other Strategic Plan Questions. The subcategory with the largest portion of funding was Molecular pathways (32%), followed by Neural systems and Subgroups/Biosignatures, which each received less than half the funding of Molecular pathways (15% and 14%, respectively). Projects related to Developmental trajectory were supported by 11% of 2010 ASD research funding, and research on Sensory and motor function received 7%. Studies on Immune/Metabolic pathways (6%), Co-occurring conditions (5%), Cognitive studies (5%), and Computational science (4%) round out the types of research in Question 2.
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
A mitochondrial etiology of autism Wallace, Douglas Q2.S.A Children's Hospital of Philadelphia
An ex-vivo placental perfusion system to study materno-fetal biology Bonnin, Alexandre Q2.S.A University of Southern California
A non-human primate autism model based on maternal immune activation Patterson, Paul Q2.S.A University of California, Davis
A non-human primate autism model based on maternal infection Patterson, Paul Q2.S.A California Institute of Technology
A primate model of gut, immune, and CNS response to childhood vaccines Sackett, Gene Q2.S.A University of Washington
A role for immune molecules in cortical connectivity: Potential implications for autism Elmer, Bradford Q2.S.A University of California, Davis
CNS toxicity of ambient air pollution: Postnatal exposure to ultrafine particles Cory-Slechta, Deborah Q2.S.A University of Rochester
Consequences of maternal antigen exposure on offspring immunity: An animal model of vertical tolerance Rall, Glenn Q2.S.A The Fox Chase Cancer Center
Does mercury and neurotension induce mitochondrial DNA release from human mast cells and contribute to auto-immunity in ASD? Theohardies, Theoharis Q2.S.A Tufts University
Early biologic markers for autism Croen, Lisa Q2.S.A Kaiser Permanente Division of Research
EFRI- BSBA: Novel microsystems for manipulation and analysis of immune cells Revzin, Alexander Q2.S.A University of California, Davis
Environmentally induced oxidative stress and altered local brain thyroid horomone metabolism: relevance to autism? Sajdel-Sulkowski, Elizabeth Q2.S.A Harvard Medical School; Brigham and Women's Hospital
Gene-environment interactions in the pathogenesis of autism-like neurodevelopmental damage: A mouse model Pletnikov, Mikhail Q2.S.A Johns Hopkins University School of Medicine
How does IL-6 mediate the development of autism-related behaviors? Hsiao, Elaine Q2.S.A California Institute of Technology
Immune molecules and cortical synaptogenesis: Possible implications for the pathogenesis of autism McAllister, A. Kimberley Q2.S.A University of California, Davis
Influence of maternal cytokines during pregnancy on effector and regulatory T helper cells as etiological factors in autism Ponzio, Nicholas Q2.S.A University of Medicine & Dentistry of New Jersey
Influence of maternal cytokines on activation of the innate immune system as a factor in the development of autism Ponzio, Nicholas Q2.S.A University of Medicine & Dentistry of New Jersey
Influence of oxidative stress on transcription and alternative splicing of methionine synthase in autism Muratore, Christina Q2.S.A Northeastern University
Influence of the maternal immune response on the development of autism Ponzio, Nicholas Q2.S.A University of Medicine & Dentistry of New Jersey
Is autism a mitochondrial disease? Giulivi, Cecilia Q2.S.A University of California, Davis
Maternal immune activation, cytokines, and the pathogenesis of autism McAllister, A. Kimberley Q2.S.A University of California, Davis
Maternal infection and autism: Impact of placental sufficiency and maternal inflammatory responses on fetal brain development Palmer, Theo Q2.S.A Stanford University
Mechanisms of mitochondrial dysfunction in autism Shoffner, John Q2.S.A Georgia State University
Molecular pathways involved in oxidative stress and leaky gut impairment in autism spectrum disorders Antonucci, Nicola Q2.S.A University of Naples
Neuroimmunologic investigations of autism spectrum disorders (ASD) Swedo, Susan Q2.S.F National Institutes of Health