Subcategory Detail
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Molecular Pathways$28,759,657.25
Fiscal Year: 2010
  

Download 2010 Molecular Pathways projects (EXCEL)
This subcategory includes studies on specific molecules and proteins (other than the immune and metabolic systems) that may be involved in the development of ASD and related genetic disorders (e.g., fragile X syndrome and Rett syndrome). Many of these projects use animal and cellular models to explore the biological effects of specific candidate genes and to identify common molecular pathways, including alterations in synaptic functioning and intracellular signaling cascades.
Graph: Question 2 encompassed a broad range of biological research, resulting in the need to create a larger number of subcategories to adequately describe the breadth of research than was required for other Strategic Plan Questions. The subcategory with the largest portion of funding was Molecular pathways (32%), followed by Neural systems and Subgroups/Biosignatures, which each received less than half the funding of Molecular pathways (15% and 14%, respectively). Projects related to Developmental trajectory were supported by 11% of 2010 ASD research funding, and research on Sensory and motor function received 7%. Studies on Immune/Metabolic pathways (6%), Co-occurring conditions (5%), Cognitive studies (5%), and Computational science (4%) round out the types of research in Question 2.
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Aberrant synaptic form and function due to TSC-mTOR-related mutation in autism spectrum disorders Sulzer, David Q2.S.D Columbia University
Aberrant synaptic function caused by TSC mutation in autism Sulzer, David Q2.S.D Columbia University
ACE Center: Cognitive affective and neurochemical processes underlying is in autism Sweeney, John Q2.Other University of Illinois at Chicago
Activity-dependent phosphorylation of MeCP2 Ebert, Daniel Q2.S.D Harvard Medical School
Allelic choice in Rett syndrome Donohoe, Mary Q2.S.D Winifred Masterson Burke Medical Research Institute
Analysis of Fgf17 roles and regulation in mammalian forebrain development Hoch, Renee Q2.Other University of California, San Francisco
Angelman syndrome (AS) Percy, Alan Q2.S.D University of Alabama at Birmingham
A sex-specific dissection of autism genetics Weiss, Lauren Q2.S.B University of California, San Francisco
A sex-specific dissection of autism genetics Weiss, Lauren Q2.S.B University of California, San Francisco
A systematic test of the relation of ASD heterogeneity to synaptic function Sudhof, Thomas; Malenka, Robert Q2.Other Stanford University
A systems biology approach to unravel the underlying functional modules of ASD Iakoucheva, Lilia Q2.Other University of California, San Diego
Augmentation of the cholinergic system in fragile X syndrome: A double-blind placebo study Reiss, Allan Q2.S.D Stanford University
Autism and the insula: Genomic and neural circuits Allman, John Q2.Other California Institute of Technology
Autism-specific mutation in DACT1: Impact on brain development in a mouse model Cheyette, Benjamin Q2.Other University of California, San Francisco
BDNF and the restoration of spine plasticity with autism spectrum disorders Gall, Christine Q2.S.D University of California, Irvine
BDNF secretion and neural precursor migration Zhao, Xuesong Q2.Other Dana-Farber Cancer Institute
Brain lipid rafts in cholesterol biosynthesis disorders Yu, Hongwei Q2.Other Medical College of Wisconsin
Cell adhesion molecules in CNS development Mueller, Ulrich Q2.Other The Scripps Research Institute
Cell-based genomic analysis in mouse models of Rett syndrome Huang, Z. Josh Q2.S.D Cold Spring Harbor Laboratory
Cell type-based genomics of developmental plasticity in cortical GABA interneurons Huang, Z. Josh Q2.Other Cold Spring Harbor Laboratory
Cellular and molecular alterations in GABAergic inhibitor circuits by mutations in MeCP2 Huang, Z. Josh Q2.S.D Cold Spring Harbor Laboratory
Cellular characterization of Caspr2 Comoletti, Davide Q2.Other University of California, San Diego
Coordinated control of synapse development by autism-linked genes Huber, Kimberly Q2.S.D University of Texas Southwestern Medical Center
Cortical circuit changes and mechanisms in a mouse model of fragile X syndrome Gibson, Jay Q2.S.D University of Texas Southwestern Medical Center
Defining cells and circuits affected in autism spectrum disorders Heintz, Nathaniel Q2.Other The Rockefeller University