Subcategory Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Subgroups/Biosignatures$12,401,288.07
Fiscal Year: 2010
  

Download 2010 Subgroups/Biosignatures projects (EXCEL)
Because there is so much heterogeneity among individuals with autism, research to understand how certain subgroups of individuals that share certain behavioral or biological characteristics could help understand some of the underlying biology in ASD. This can be done by searching for certain biological factors ("signatures"), such as hormone levels or structural abnormalities in the brain, that define a particular subgroup. Many of these projects try to make the connection between certain genes with a known or suspected link to autism and the observable characteristic, or phenotype, that they cause.
Graph: Question 2 encompassed a broad range of biological research, resulting in the need to create a larger number of subcategories to adequately describe the breadth of research than was required for other Strategic Plan Questions. The subcategory with the largest portion of funding was Molecular pathways (32%), followed by Neural systems and Subgroups/Biosignatures, which each received less than half the funding of Molecular pathways (15% and 14%, respectively). Projects related to Developmental trajectory were supported by 11% of 2010 ASD research funding, and research on Sensory and motor function received 7%. Studies on Immune/Metabolic pathways (6%), Co-occurring conditions (5%), Cognitive studies (5%), and Computational science (4%) round out the types of research in Question 2.
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
ACE Center: Genetic contributions to endophenotypes of autism Wijsman, Ellen Q2.S.G University of Washington
ACE Center: Genetics of language & social communication: Connecting genes to brain & cognition Geschwind, Daniel Q2.S.G University of California, Los Angeles
ACE Center: Genetics of serotonin in autism: Neurochemical and clinical endophenotypes Cook, Edwin Q2.S.G University of Illinois at Chicago
A family-genetic study of language in autism Losh, Molly Q2.S.G University of North Carolina at Chapel Hill
A family-genetic study of language in autism Losh, Molly Q2.S.G Northwestern University
A multigenerational longitudinal study of language development: Insight from autism Losh, Molly Q2.S.G University of North Carolina at Chapel Hill
A multigenerational longitudinal study of language development: Insight from autism Losh, Molly Q2.S.G Northwestern University
A neuroimaging study of twin pairs with autism Hardan, Antonio Q2.S.G Stanford University
An investigation of the overlap of autism and fragile X syndrome Martin, Gary Q2.S.G University of North Carolina at Chapel Hill
A study of autism Krieger, Abba Q2.L.B University of Pennsylvania
Autism: Neuropeptide hormones and potential pathway genes Jacob, Suma Q2.S.G University of Illinois at Chicago
Autism: Neuropeptide hormones and potential pathway genes (supplement) Jacob, Suma Q2.S.G University of Illinois at Chicago
Autism: The neural substrates of language in siblings Lindgren, Kristen Q2.S.G Boston University Medical Campus
Autistic endophenotypes and their associations to oxytocin and cholesterol Silverman, Jeremy Q2.Other Mount Sinai School of Medicine
Behavioral and genetic biomarker development for autism and related disorders Brzustowicz, Linda Q2.S.G Rutgers, The State University of New Jersey - New Brunswick
Creating a specimen bank of neurotypical individuals Russo, A.J. Q2.Other Health Research Institute
fMRI evidence of genetic influence on rigidity in ASD Lee, Jillian Q2.S.G University of Michigan
Functional imaging of flexibility in autism: Informed by SLC6A4 Yerys, Benjamin Q2.S.G Children's Research Institute
Functional neuroimaging of psychopharmacologic intervention for autism Dichter, Gabriel Q2.L.B University of North Carolina at Chapel Hill
Gamma band dysfunction as a local neuronal connectivity endophenotype in autism Rojas, Donald Q2.Other University of Colorado Denver
Genetic dissection of restricted repetitive behavior (RRB) Kim, Soo-Jeong Q2.S.G University of Florida
Genotype-phenotype relationships in fragile X families Hagerman, Randi Q2.S.D University of California, Davis
Identifying brain-based biomarkers for ASD & their biological subtypes Peterson, Bradley Q2.Other New York State Psychiatric Institute
Interdisciplinary investigation of biological signatures of autism subtypes Amaral, David; Rogers, Sally; Van de Water, Judy Q2.L.A University of California, Davis
Language processing in children with 22q11 deletion syndrome and autism Ousley, Opal Q2.S.G Emory University