Subcategory Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Model Systems/Therapeutic Targets$24,115,793.04
Fiscal Year: 2010
  

Download 2010 Model Systems/Therapeutic Targets projects (EXCEL)
Animal models mimicking behaviors of ASD and those that are being used to develop or test new drug treatments, as well as cell lines used to discover new drug targets or to screen potential drug candidates, are included in this subcategory.
Graph: The subcategories for Question 4 illustrate the many approaches to treatments and interventions supported by autism research funders. The largest amount of funding supported projects to develop Model systems and therapeutic targets (35%), followed by research on Behavioral interventions (29%). Medical/Pharmacologic interventions received 16% of funding, classroom-based interventions (Educational) received 10% of funding, and Technology-based interventions and supports received 7% of funding. The subcategories with the smallest amounts of funding included Occupational, physical, and sensory-based (2%) and Complementary, dietary, and alternative (1%).
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Vasopressin receptors and social attachment Young, Larry Q4.S.B Emory University
Using zebrafish and chemical screening to define function of autism genes Sive, Hazel Q4.S.B Whitehead Institute for Biomedical Research
Using iPS cells to study genetically defined forms with autism Dolmetsch, Ricardo Q4.S.B Stanford University
Using induced pluripotent stem cells to identify cellular phenotypes of autism Dolmetsch, Ricardo Q4.S.B Stanford University
Using Drosophila to model the synaptic function of the autism-linked NHE9 Littleton, J. Troy Q4.S.B Massachusetts Institute of Technology
Transgenic mouse model to address heterogeneity in autism spectrum disorders Blakely, Randy Q4.S.B Vanderbilt University
The role of SHANK3 in the etiology of autism spectrum disorder Bangash, M. Ali Q4.S.B Johns Hopkins University
The role of SHANK3 in autism spectrum disorders Buxbaum, Joseph Q4.S.B Mount Sinai School of Medicine
The genetics of restricted, repetitive behavior: An inbred mouse model Lewis, Mark Q4.S.B University of Florida
The genetic control of social behavior in the mouse Blanchard, Robert Q4.S.B University of Hawai'i at Manoa
Systematic analysis of neural circuitry in mouse models of autism Osten, Pavel Q4.S.B Cold Spring Harbor Laboratory
Synaptic plasticity, memory and social behavior Chevere-Torres, Itzamarie Q4.S.B New York University
Synaptic deficits of iPS cell-derived neurons from patients with autism Mao, Rong Q4.S.B Stanford University
Synaptic and circuitry mechanisms of repetitive behaviors in autism Feng, Guoping Q4.S.B Massachusetts Institute of Technology
Small-molecule compounds for treating autism spectrum disorders Philpot, Ben Q4.S.B The University of North Carolina at Chapel Hill
Shank3 mutant characterization in vivo Kouser, Mehreen Q4.S.B University of Texas Southwestern Medical Center
Serotonin, corpus callosum, and autism Lin, Rick Q4.S.B University of Mississippi Medical Center
Serotonin, autism, and investigating cell types for CNS disorders Dougherty, Joseph Q4.S.B The Rockefeller University
Role of UBE3A in neocortical plasticity and function Ehlers, Michael Q4.S.B Duke University
Role of L-type calcium channels in hippocampal neuronal network activity Owen, Scott Q4.S.B Stanford University
Role of a novel Wnt pathway in autism spectrum disorders Reichardt, Louis Q4.S.B University of California, San Francisco
Regulation of gene expression in the brain Young, Walter Q4.S.B National Institutes of Health
Preclinical testing of novel oxytocin receptor activators in models of autism phenotypes Pedersen, Cort Q4.S.B University of North Carolina at Chapel Hill
Preclinical testing of novel oxytocin receptor activators in models of autism phenotypes Jarstfer, Michael Q4.S.B University of North Carolina at Chapel Hill
Preclinical testing of novel oxytocin receptor activators in models of autism phenotypes Moy, Sheryl Q4.S.B University of North Carolina at Chapel Hill