Subcategory Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Model Systems/Therapeutic Targets$24,115,793.04
Fiscal Year: 2010
  

Download 2010 Model Systems/Therapeutic Targets projects (EXCEL)
Animal models mimicking behaviors of ASD and those that are being used to develop or test new drug treatments, as well as cell lines used to discover new drug targets or to screen potential drug candidates, are included in this subcategory.
Graph: The subcategories for Question 4 illustrate the many approaches to treatments and interventions supported by autism research funders. The largest amount of funding supported projects to develop Model systems and therapeutic targets (35%), followed by research on Behavioral interventions (29%). Medical/Pharmacologic interventions received 16% of funding, classroom-based interventions (Educational) received 10% of funding, and Technology-based interventions and supports received 7% of funding. The subcategories with the smallest amounts of funding included Occupational, physical, and sensory-based (2%) and Complementary, dietary, and alternative (1%).
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
16p11.2: defining the gene(s) responsible Mills, Alea Q4.S.B Cold Spring Harbor Laboratory
A mouse knock-in model for ENGRAILED 2 autism susceptibility Millonig, James Q4.S.B University of Medicine & Dentistry of New Jersey
Analysis of cortical circuits related to ASD gene candidates Zador, Anthony Q4.S.B Cold Spring Harbor Laboratory
Animal model of speech sound processing in autism Kilgard, Michael Q4.S.B University of Texas at Dallas
Animal models of autism: Pathogenesis and treatment Powell, Craig Q4.S.B University of Texas Southwestern Medical Center
Animal models of neuropsychiatric disorders Crawley, Jacqueline Q4.S.B National Institutes of Health
A novel cell-based assay for autism research and drug discovery Restifo, Linda Q4.S.B University of Arizona
A preclinical model for determining the role of AVPR1A in autism spectrum disorders Charles, Rhonda Q4.S.B Mount Sinai School of Medicine
Autism iPSCs for studying function and dysfunction in human neural development Loring, Jeanne Q4.S.B The Scripps Research Institute
Basal ganglia circuitry and molecules in pathogenesis of motor stereotypy Yang, Xiangdong Q4.S.B University of California, Los Angeles
Behavioral and physiological consequences of disrupted Met signaling Levitt, Pat Q4.S.B University of Southern California
Caspr2 dysfunction in autism spectrum disorders Robbins, Elissa Q4.S.B Yale University
Cellular and genetic correlates of increased head size in autism spectrum disorder Vaccarino, Flora Q4.S.B Yale University
Central vasopressin receptors and affiliation Young, Larry Q4.S.B Emory University
Central vasopressin receptors and affiliation Young, Larry Q4.S.B Emory University
Characterization of a novel mouse model of restricted repetitive behaviors Moy, Sheryl Q4.S.B University of North Carolina at Chapel Hill
Characterization of autism susceptibility genes on chromosome 15q11-13 Smith, Stephen Q4.S.B Beth Israel Deaconess Medical Center
Characterization of the transcriptome in an emerging model for social behavior Thomas, James Q4.S.B Emory University
Cntnap2 in a behavioral model of autism White, Stephanie Q4.S.B University of California, Los Angeles
Control of synaptic protein synthesis in the pathogenesis and therapy of autism Kelleher, Raymond Q4.S.B Massachusetts General Hospital
Deriving neuroprogenitor cells from peripheral blood of individuals with autism Fujinami, Robert Q4.S.B University of Utah
Design & synthesis of novel CNS-active oxytocin and vasopressin receptor ligands Roberts, Edward Q4.Other The Scripps Research Institute
Development of a high-content neuronal assay to screen therapeutics for the treatment of cognitive dysfunction in autism spectrum disorders Bear, Mark Q4.S.B Massachusetts Institute of Technology
Dissecting the circuitry basis of autistic-like behaviors in mice Feng, Guoping Q4.S.B Massachusetts Institute of Technology
Dissecting the neural control of social attachment Shah, Nirao Q4.S.B University of California, San Francisco