Subcategory Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Subgroups/Biosignatures$12,401,288.07
Fiscal Year: 2010
  

Download 2010 Subgroups/Biosignatures projects (EXCEL)
Because there is so much heterogeneity among individuals with autism, research to understand how certain subgroups of individuals that share certain behavioral or biological characteristics could help understand some of the underlying biology in ASD. This can be done by searching for certain biological factors ("signatures"), such as hormone levels or structural abnormalities in the brain, that define a particular subgroup. Many of these projects try to make the connection between certain genes with a known or suspected link to autism and the observable characteristic, or phenotype, that they cause.
Graph: Question 2 encompassed a broad range of biological research, resulting in the need to create a larger number of subcategories to adequately describe the breadth of research than was required for other Strategic Plan Questions. The subcategory with the largest portion of funding was Molecular pathways (32%), followed by Neural systems and Subgroups/Biosignatures, which each received less than half the funding of Molecular pathways (15% and 14%, respectively). Projects related to Developmental trajectory were supported by 11% of 2010 ASD research funding, and research on Sensory and motor function received 7%. Studies on Immune/Metabolic pathways (6%), Co-occurring conditions (5%), Cognitive studies (5%), and Computational science (4%) round out the types of research in Question 2.
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Genotype-phenotype relationships in fragile X families Hagerman, Randi Q2.S.D University of California, Davis
Vaccination with regression study Davis, Robert Q2.S.F Kaiser Permanente Georgia
Behavioral and genetic biomarker development for autism and related disorders Brzustowicz, Linda Q2.S.G Rutgers, The State University of New Jersey - New Brunswick
ACE Center: Genetics of serotonin in autism: Neurochemical and clinical endophenotypes Cook, Edwin Q2.S.G University of Illinois at Chicago
Neural circuitry of social cognition in the broad autism phenotype Piven, Joseph Q2.S.G University of North Carolina at Chapel Hill
Simons Variation in Individuals Project (VIP) Site Bernier, Raphael Q2.S.G University of Washington
Neural and phenotypic correlates of autism risk genes Bookheimer, Susan Q2.S.G University of California, Los Angeles
Longitudinal neurogenetics of atypical social brain development in autism Pelphrey, Kevin Q2.S.G Yale University
Language processing in children with 22q11 deletion syndrome and autism Ousley, Opal Q2.S.G Emory University
Neural correlates of serotonin transporter gene polymorphisms and social impairment in ASD Monk, Christopher Q2.S.G University of Michigan
The genetic link between autism and structural cerebellar malformations Millen, Kathleen Q2.S.G University of Chicago
A family-genetic study of language in autism Losh, Molly Q2.S.G University of North Carolina at Chapel Hill
A family-genetic study of language in autism Losh, Molly Q2.S.G Northwestern University
A multigenerational longitudinal study of language development: Insight from autism Losh, Molly Q2.S.G University of North Carolina at Chapel Hill
A multigenerational longitudinal study of language development: Insight from autism Losh, Molly Q2.S.G Northwestern University
Autism: The neural substrates of language in siblings Lindgren, Kristen Q2.S.G Boston University Medical Campus
fMRI evidence of genetic influence on rigidity in ASD Lee, Jillian Q2.S.G University of Michigan
Genetic dissection of restricted repetitive behavior (RRB) Kim, Soo-Jeong Q2.S.G University of Florida
Simons Variation in Individual Project (Simons VIP) Core Leader Gift Hanson, Ellen Q2.S.G Children's Hospital Boston
Simons Variation in Individuals Project (Simons VIP) Lese Martin, Christa Q2.S.G Emory University
Neural correlates of restricted, repetitive behaviors in autism spectrum disorders Manoach, Dara Q2.S.G Massachusetts General Hospital
An investigation of the overlap of autism and fragile X syndrome Martin, Gary Q2.S.G University of North Carolina at Chapel Hill
Social cognition in 22q11.2 deletion syndrom (DS) adolescents with ASD vs. without ASD: Imaging and genetic correlates Radoeva, Petya Q2.S.G State University of New York Upstate Medical University
Simons Variation in Individuals Project (Simons VIP) Core Leader Gift Sherr, Elliott Q2.S.G University of California, San Francisco
Functional imaging of flexibility in autism: Informed by SLC6A4 Yerys, Benjamin Q2.S.G Children's Research Institute