Subcategory Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Subgroups/Biosignatures$12,401,288.07
Fiscal Year: 2010
  

Download 2010 Subgroups/Biosignatures projects (EXCEL)
Because there is so much heterogeneity among individuals with autism, research to understand how certain subgroups of individuals that share certain behavioral or biological characteristics could help understand some of the underlying biology in ASD. This can be done by searching for certain biological factors ("signatures"), such as hormone levels or structural abnormalities in the brain, that define a particular subgroup. Many of these projects try to make the connection between certain genes with a known or suspected link to autism and the observable characteristic, or phenotype, that they cause.
Graph: Question 2 encompassed a broad range of biological research, resulting in the need to create a larger number of subcategories to adequately describe the breadth of research than was required for other Strategic Plan Questions. The subcategory with the largest portion of funding was Molecular pathways (32%), followed by Neural systems and Subgroups/Biosignatures, which each received less than half the funding of Molecular pathways (15% and 14%, respectively). Projects related to Developmental trajectory were supported by 11% of 2010 ASD research funding, and research on Sensory and motor function received 7%. Studies on Immune/Metabolic pathways (6%), Co-occurring conditions (5%), Cognitive studies (5%), and Computational science (4%) round out the types of research in Question 2.
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Autism: The neural substrates of language in siblings Lindgren, Kristen Q2.S.G Boston University Medical Campus
The neural substrates of repetitive behaviors in autism Dominick, Kelli Q2.Other Boston University Medical Campus
Towards an endophenotype for amygdala dysfunction Adolphs, Ralph Q2.Other California Institute of Technology
Simons Variation in Individual Project (Simons VIP) Core Leader Gift Hanson, Ellen Q2.S.G Children's Hospital Boston
Functional imaging of flexibility in autism: Informed by SLC6A4 Yerys, Benjamin Q2.S.G Children's Research Institute
Simons Variation in Individuals Project (Simons VIP) Principal Investigator Gift Chung, Wendy Q2.S.G Columbia University
Language processing in children with 22q11 deletion syndrome and autism Ousley, Opal Q2.S.G Emory University
Simons Variation in Individuals Project (Simons VIP) Lese Martin, Christa Q2.S.G Emory University
Creating a specimen bank of neurotypical individuals Russo, A.J. Q2.Other Health Research Institute
Vaccination with regression study Davis, Robert Q2.S.F Kaiser Permanente Georgia
Neural correlates of restricted, repetitive behaviors in autism spectrum disorders Manoach, Dara Q2.S.G Massachusetts General Hospital
Neural correlates of restricted, repetitive behaviors in autism spectrum disorders Santangelo, Susan Q2.S.G Massachusetts General Hospital
Autistic endophenotypes and their associations to oxytocin and cholesterol Silverman, Jeremy Q2.Other Mount Sinai School of Medicine
Identifying brain-based biomarkers for ASD & their biological subtypes Peterson, Bradley Q2.Other New York State Psychiatric Institute
A family-genetic study of language in autism Losh, Molly Q2.S.G Northwestern University
A multigenerational longitudinal study of language development: Insight from autism Losh, Molly Q2.S.G Northwestern University
Behavioral and genetic biomarker development for autism and related disorders Brzustowicz, Linda Q2.S.G Rutgers, The State University of New Jersey - New Brunswick
Linking local activity and functional connectivity in autism Mueller, Ralph-Axel Q2.Other San Diego State University
The genetic basis of mid-hindbrain malformations Dobyns, William Q2.S.G Seattle Children's Hospital
A neuroimaging study of twin pairs with autism Hardan, Antonio Q2.S.G Stanford University
Social cognition in 22q11.2 deletion syndrom (DS) adolescents with ASD vs. without ASD: Imaging and genetic correlates Radoeva, Petya Q2.S.G State University of New York Upstate Medical University
Genotype-phenotype relationships in fragile X families Hagerman, Randi Q2.S.D University of California, Davis
Interdisciplinary investigation of biological signatures of autism subtypes Amaral, David; Rogers, Sally; Van de Water, Judy Q2.L.A University of California, Davis
Neural and phenotypic correlates of autism risk genes Bookheimer, Susan Q2.S.G University of California, Los Angeles
ACE Center: Genetics of language & social communication: Connecting genes to brain & cognition Geschwind, Daniel Q2.S.G University of California, Los Angeles