Subcategory Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Model Systems/Therapeutic Targets$24,115,793.04
Fiscal Year: 2010
  

Download 2010 Model Systems/Therapeutic Targets projects (EXCEL)
Animal models mimicking behaviors of ASD and those that are being used to develop or test new drug treatments, as well as cell lines used to discover new drug targets or to screen potential drug candidates, are included in this subcategory.
Graph: The subcategories for Question 4 illustrate the many approaches to treatments and interventions supported by autism research funders. The largest amount of funding supported projects to develop Model systems and therapeutic targets (35%), followed by research on Behavioral interventions (29%). Medical/Pharmacologic interventions received 16% of funding, classroom-based interventions (Educational) received 10% of funding, and Technology-based interventions and supports received 7% of funding. The subcategories with the smallest amounts of funding included Occupational, physical, and sensory-based (2%) and Complementary, dietary, and alternative (1%).
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Caspr2 dysfunction in autism spectrum disorders Robbins, Elissa Q4.S.B Yale University
Integrated approach to the neurobiology of autism spectrum disorders Vaccarino, Flora Q4.S.B Yale University
Cellular and genetic correlates of increased head size in autism spectrum disorder Vaccarino, Flora Q4.S.B Yale University
Using zebrafish and chemical screening to define function of autism genes Sive, Hazel Q4.S.B Whitehead Institute for Biomedical Research
Transgenic mouse model to address heterogeneity in autism spectrum disorders Blakely, Randy Q4.S.B Vanderbilt University
Mouse genetic model of a dysregulated serotonin transporter variant associated with autism Veenstra-Vanderweele, Jeremy Q4.S.B Vanderbilt University
Murine genetic models of autism Veenstra-Vanderweele, Jeremy Q4.S.B Vanderbilt University
Evaluation of altered fatty acid metabolism via gas chromatography/mass spectroscopy and time-of-flight secondary ion mass spectroscopy imaging in the propionic acid rat model of autism spectrum disorders MacFabe, Derrick Q4.S.B University of Western Ontario
Deriving neuroprogenitor cells from peripheral blood of individuals with autism Fujinami, Robert Q4.S.B University of Utah
Shank3 mutant characterization in vivo Kouser, Mehreen Q4.S.B University of Texas Southwestern Medical Center
Identifying impairments in synaptic connectivity in mouse models of ASD Speed, Haley Q4.S.B University of Texas Southwestern Medical Center
Animal models of autism: Pathogenesis and treatment Powell, Craig Q4.S.B University of Texas Southwestern Medical Center
Novel genetic animal models of autism Powell, Craig Q4.S.B University of Texas Southwestern Medical Center
Neuroligin function in vivo: Implications for autism and mental retardation Powell, Craig Q4.S.B University of Texas Southwestern Medical Center
Animal model of speech sound processing in autism Kilgard, Michael Q4.S.B University of Texas at Dallas
Behavioral and physiological consequences of disrupted Met signaling Levitt, Pat Q4.S.B University of Southern California
Neurobiology of sociability in a mouse model system relevant to autism Brodkin, Edward Q4.S.B University of Pennsylvania
High-resolution diffusion tensor imaging in mouse models relevant to autism Poptani, Harish Q4.S.B University of Pennsylvania
Functional genomic dissection of language-related disorders Fisher, Simon Q4.S.B University of Oxford
Neuropharmacology of motivation and reinforcement in mouse models of autistic spectrum disorders Malanga, C.J. Q4.S.B University of North Carolina School of Medicine
Preclinical testing of novel oxytocin receptor activators in models of autism phenotypes Pedersen, Cort Q4.S.B University of North Carolina at Chapel Hill
Novel strategies to manipulate Ube3a expression for the treatment of autism and Angelman syndrome Roth, Bryan Q4.S.B University of North Carolina at Chapel Hill
Preclinical testing of novel oxytocin receptor activators in models of autism phenotypes Jarstfer, Michael Q4.S.B University of North Carolina at Chapel Hill
NrCAM, a candidate susceptibility gene for visual processing deficits in autism Maness, Patricia Q4.S.B University of North Carolina at Chapel Hill
Preclinical testing of novel oxytocin receptor activators in models of autism phenotypes Moy, Sheryl Q4.S.B University of North Carolina at Chapel Hill