Subcategory Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Model Systems/Therapeutic Targets$24,115,793.04
Fiscal Year: 2010
  

Download 2010 Model Systems/Therapeutic Targets projects (EXCEL)
Animal models mimicking behaviors of ASD and those that are being used to develop or test new drug treatments, as well as cell lines used to discover new drug targets or to screen potential drug candidates, are included in this subcategory.
Graph: The subcategories for Question 4 illustrate the many approaches to treatments and interventions supported by autism research funders. The largest amount of funding supported projects to develop Model systems and therapeutic targets (35%), followed by research on Behavioral interventions (29%). Medical/Pharmacologic interventions received 16% of funding, classroom-based interventions (Educational) received 10% of funding, and Technology-based interventions and supports received 7% of funding. The subcategories with the smallest amounts of funding included Occupational, physical, and sensory-based (2%) and Complementary, dietary, and alternative (1%).
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Dynamic regulation of Shank3 and ASD Worley, Paul Q4.S.B Johns Hopkins University
Evaluation of altered fatty acid metabolism via gas chromatography/mass spectroscopy and time-of-flight secondary ion mass spectroscopy imaging in the propionic acid rat model of autism spectrum disorders MacFabe, Derrick Q4.S.B University of Western Ontario
Exploring the neuronal phenotype of autism spectrum disorders using induced pluripotent stem cells Hallmayer, Joachim; Dolmetsch, Ricardo Q4.S.B Stanford University
Functional genomic dissection of language-related disorders Fisher, Simon Q4.S.B University of Oxford
Functional study of synaptic scaffold protein SHANK3 and autism mouse model Jiang, Yong-Hui Q4.S.B Duke University
Function and dysfunction of neuroligins Sudhof, Thomas Q4.S.B Stanford University
Genetic models of serotonin transporter regulation linked to mental disorders Ramamoorthy, Sammanda Q4.S.B Medical University of South Carolina
Genomic imbalances at the 22q11 locus and predisposition to autism Gogos, Joseph Q4.S.B Columbia University
Genomic resources for identifying genes regulating social behavior Young, Larry Q4.S.B Emory University
High content screens of neuronal development for autism research Halpain, Shelley Q4.S.B University of California, San Diego
High-resolution diffusion tensor imaging in mouse models relevant to autism Poptani, Harish Q4.S.B University of Pennsylvania
Identification of autism genes that regulate synaptic Nrx/Nlg signaling complexes Garner, Craig Q4.S.B Stanford University
Identifying genetic modifiers of rett syndrome in the mouse Buchovecky, Christine Q4.S.B Baylor College of Medicine
Identifying impairments in synaptic connectivity in mouse models of ASD Speed, Haley Q4.S.B University of Texas Southwestern Medical Center
Insight into MeCP2 function raises therapeutic possibilities for Rett syndrome Lomvardas, Stavros Q4.S.B University of California, San Francisco
Integrated approach to the neurobiology of autism spectrum disorders Vaccarino, Flora Q4.S.B Yale University
Interaction between MEF2 and MECP2 in the pathogenesis of autism spectrum disorders - 1 Lipton, Stuart Q4.S.B Burnham Institute
Interaction between MEF2 and MECP2 in the pathogenesis of autism spectrum disorders -2 Nakanishi, Nobuki Q4.S.B Burnham Institute
Investigating the effects of chromosome 22q11.2 deletions Karayiorgou, Maria Q4.S.B Columbia University
Investigation of the role of MET kinase in autism Dawson, Ted Q4.S.B Johns Hopkins University School of Medicine
Methods for production of ICSI and SCNT derived macaque stem cells Schatten, Gerald Q4.S.B Southwest Foundation For Biomedical Research
Mice lacking Shank postsynaptic scaffolds as an animal model of autism Sheng, Morgan Q4.S.B Massachusetts Institute of Technology
Micro-RNA regulation in pluripotent stem cells Schatten, Gerald Q4.S.B Southwest Foundation For Biomedical Research
Modeling and pharmacologic treatment of autism spectrum disorders in Drosophila McDonald, Thomas Q4.S.B Albert Einstein College of Medicine of Yeshiva University
Mouse genetic model of a dysregulated serotonin transporter variant associated with autism Veenstra-Vanderweele, Jeremy Q4.S.B Vanderbilt University