Subcategory Detail
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Office of Autism Research Coordination (OARC) logo

Molecular Pathways$28,759,657.25
Fiscal Year: 2010
  

Download 2010 Molecular Pathways projects (EXCEL)
This subcategory includes studies on specific molecules and proteins (other than the immune and metabolic systems) that may be involved in the development of ASD and related genetic disorders (e.g., fragile X syndrome and Rett syndrome). Many of these projects use animal and cellular models to explore the biological effects of specific candidate genes and to identify common molecular pathways, including alterations in synaptic functioning and intracellular signaling cascades.
Graph: Question 2 encompassed a broad range of biological research, resulting in the need to create a larger number of subcategories to adequately describe the breadth of research than was required for other Strategic Plan Questions. The subcategory with the largest portion of funding was Molecular pathways (32%), followed by Neural systems and Subgroups/Biosignatures, which each received less than half the funding of Molecular pathways (15% and 14%, respectively). Projects related to Developmental trajectory were supported by 11% of 2010 ASD research funding, and research on Sensory and motor function received 7%. Studies on Immune/Metabolic pathways (6%), Co-occurring conditions (5%), Cognitive studies (5%), and Computational science (4%) round out the types of research in Question 2.
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Aberrant synaptic form and function due to TSC-mTOR-related mutation in autism spectrum disorders Sulzer, David Q2.S.D Columbia University
A systematic test of the relation of ASD heterogeneity to synaptic function Sudhof, Thomas; Malenka, Robert Q2.Other Stanford University
Function and dysfunction of neuroligins in synaptic circuits Sudhof, Thomas Q2.Other Stanford University
Function of neurexins Sudhof, Thomas Q2.Other Stanford University
Role of neuronal migration genes in synaptogenesis and plasticity Sudarov, Anamaria Q2.Other Weill Cornell Medical College
Studies on protein synthesis and long-term adaptive responses in the CNS Smith, Carolyn Q2.Other National Institutes of Health
Investigation of postnatal drug intervention's potential in rescuing the symptoms of fragile X syndrome in adult mice Sidorov, Michael Q2.S.D Massachusetts Institute of Technology
Glial control of neuronal receptive ending morphology Shaham, Shai Q2.Other The Rockefeller University
New approaches to local translation: SpaceSTAMP of proteins synthesized in axons Segal, Rosalind Q2.S.D Dana-Farber Cancer Institute
Visual system connectivity in a high-risk model of autism Sahin, Mustafa Q2.S.D Children's Hospital Boston
Perturbed activity-dependent plasticity mechanisms in autism Sabatini, Bernardo Q2.Other Harvard Medical School
Regulation of activity-dependent ProSAP2 synaptic dynamics Rowan, Magali Q2.Other Stanford University
Olfactory abnormalities in the modeling of Rett syndrome Ronnett, Gabriele Q2.S.D Johns Hopkins University
Proteomics in drosophila to identify autism candidate substrates of UBE3A Reiter, Lawrence Q2.S.D University of Tennessee Health Science Center
Augmentation of the cholinergic system in fragile X syndrome: A double-blind placebo study Reiss, Allan Q2.S.D Stanford University
Serotonin signal transduction in two groups of autistic patients Rasenick, Mark Q2.Other University of Illinois at Chicago
Role of neuroligin in synapse stability Rand, James Q2.Other Oklahoma Medical Research Foundation
Role of Pam in synaptic morphology and function Ramesh, Vijaya Q2.Other Massachusetts General Hospital
Met signaling in neural development and circuitry formation Qiu, Shenfeng Q2.Other University of Southern California
MeCP2 modulation of BDNF signaling: Shared mechanisms of Rett and autism Pozzo-Miller, Lucas Q2.S.D University of Alabama at Birmingham
Angelman syndrome (AS) Percy, Alan Q2.S.D University of Alabama at Birmingham
Glutamate receptor desensitization and its modulation Partin, Kathryn Q2.Other Colorado State University
Elucidating the function of class 4 semaphorins in GABAergic synapse formation Paradis, Suzanne Q2.Other Brandeis University
Mouse models of human autism spectrum disorders: Gene targeting in specific brain regions Parada, Luis Q2.S.D University of Texas Southwestern Medical Center
L-type calcium channel regulation of neuronal differentiation Panagiotakos, Georgia Q2.S.D Stanford University