Subcategory Detail
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Office of Autism Research Coordination (OARC) logo

Molecular Pathways$28,759,657.25
Fiscal Year: 2010
  

Download 2010 Molecular Pathways projects (EXCEL)
This subcategory includes studies on specific molecules and proteins (other than the immune and metabolic systems) that may be involved in the development of ASD and related genetic disorders (e.g., fragile X syndrome and Rett syndrome). Many of these projects use animal and cellular models to explore the biological effects of specific candidate genes and to identify common molecular pathways, including alterations in synaptic functioning and intracellular signaling cascades.
Graph: Question 2 encompassed a broad range of biological research, resulting in the need to create a larger number of subcategories to adequately describe the breadth of research than was required for other Strategic Plan Questions. The subcategory with the largest portion of funding was Molecular pathways (32%), followed by Neural systems and Subgroups/Biosignatures, which each received less than half the funding of Molecular pathways (15% and 14%, respectively). Projects related to Developmental trajectory were supported by 11% of 2010 ASD research funding, and research on Sensory and motor function received 7%. Studies on Immune/Metabolic pathways (6%), Co-occurring conditions (5%), Cognitive studies (5%), and Computational science (4%) round out the types of research in Question 2.
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Probing a monogenic form of autism from molecules to behavior Tsien, Richard Q2.S.D Stanford University
Gene silencing in fragile X syndrome Usdin, Karen Q2.S.D National Institutes of Health
The role of the autism-associated gene tuberous sclerosis complex 2 (TSC2) in presynaptic development Williams, Megan Q2.S.D University of California, San Diego
Neural circuit deficits in animal models of Rett syndrome Xiong, Qiaojie Q2.S.D Cold Spring Harbor Laboratory
Functional circuit disorders of sensory cortex in ASD and RTT Carlson, Gregory Q2.S.D University of Pennsylvania
Elucidating the roles of SHANK3 and FXR in the autism interactome Zoghbi, Huda Q2.S.D Baylor College of Medicine
Elucidation and rescue of amygdala abnormalities in the Fmr1 mutant mouse model of fragile X syndrome Corbin, Joshua Q2.S.D George Washington University
Synaptic phenotype, development, and plasticity in the fragile X mouse Cox, Charles Q2.S.D University of Illinois at Urbana Champaign
The functional link between DISC1 and neuroligins: Two genetic factors in the etiology of autism DiDonato, Christine Q2.S.D Children's Memorial Hospital, Chicago
Allelic choice in Rett syndrome Donohoe, Mary Q2.S.D Winifred Masterson Burke Medical Research Institute
Activity-dependent phosphorylation of MeCP2 Ebert, Daniel Q2.S.D Harvard Medical School
Establishing zebrafish as a model for RAI1 gene dosage Elsea, Sarah; Lister, James Q2.S.D Virginia Commonwealth University
BDNF and the restoration of spine plasticity with autism spectrum disorders Gall, Christine Q2.S.D University of California, Irvine
The microRNA pathway in translational regulation of neuronal development Gao, Fen-Biao Q2.S.D University of Massachusetts Medical School
The microRNA pathway in translational regulation of neuronal development Gao, Fen-Biao Q2.S.D J. David Gladstone Institutes
Cortical circuit changes and mechanisms in a mouse model of fragile X syndrome Gibson, Jay Q2.S.D University of Texas Southwestern Medical Center
Neuronal activity-dependent regulation of MeCP2 (supplement) Greenberg, Michael Q2.S.D Harvard Medical School
Neuronal activity-dependent regulation of MeCP2 Greenberg, Michael Q2.S.D Harvard Medical School
Fundamental mechanisms of GPR56 activation and regulation Hall, Randy Q2.S.D Emory University
Cellular and molecular alterations in GABAergic inhibitor circuits by mutations in MeCP2 Huang, Z. Josh Q2.S.D Cold Spring Harbor Laboratory
Cell-based genomic analysis in mouse models of Rett syndrome Huang, Z. Josh Q2.S.D Cold Spring Harbor Laboratory
Study of fragile X mental retardation protein in synaptic function and plasticity Huber, Kimberly Q2.S.D University of Texas Southwestern Medical Center
Coordinated control of synapse development by autism-linked genes Huber, Kimberly Q2.S.D University of Texas Southwestern Medical Center
Developmental versus acute mechanisms mediating altered excitatory synaptic function in the fragile X syndrome mouse model Huber, Kimberly Q2.S.D University of Texas Southwestern Medical Center
MicroRNAs in synaptic plasticity and behaviors relevant to autism Kelleher, Raymond Q2.S.D Massachusetts General Hospital