Subcategory Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Model Systems/Therapeutic Targets$24,115,793.04
Fiscal Year: 2010
  

Download 2010 Model Systems/Therapeutic Targets projects (EXCEL)
Animal models mimicking behaviors of ASD and those that are being used to develop or test new drug treatments, as well as cell lines used to discover new drug targets or to screen potential drug candidates, are included in this subcategory.
Graph: The subcategories for Question 4 illustrate the many approaches to treatments and interventions supported by autism research funders. The largest amount of funding supported projects to develop Model systems and therapeutic targets (35%), followed by research on Behavioral interventions (29%). Medical/Pharmacologic interventions received 16% of funding, classroom-based interventions (Educational) received 10% of funding, and Technology-based interventions and supports received 7% of funding. The subcategories with the smallest amounts of funding included Occupational, physical, and sensory-based (2%) and Complementary, dietary, and alternative (1%).
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Novel strategies to manipulate Ube3a expression for the treatment of autism and Angelman syndrome Roth, Bryan Q4.S.B University of North Carolina at Chapel Hill
Methods for production of ICSI and SCNT derived macaque stem cells Schatten, Gerald Q4.S.B Southwest Foundation For Biomedical Research
Optimization of methods for production of both ICSI- and SCNT derived baboon embryonic stem cells Schatten, Gerald Q4.S.B Southwest Foundation For Biomedical Research
Micro-RNA regulation in pluripotent stem cells Schatten, Gerald Q4.S.B Southwest Foundation For Biomedical Research
Characterization of autism susceptibility genes on chromosome 15q11-13 Smith, Stephen Q4.S.B Beth Israel Deaconess Medical Center
Identifying impairments in synaptic connectivity in mouse models of ASD Speed, Haley Q4.S.B University of Texas Southwestern Medical Center
Caspr2 dysfunction in autism spectrum disorders Robbins, Elissa Q4.S.B Yale University
Dissecting the neural control of social attachment Shah, Nirao Q4.S.B University of California, San Francisco
Mice lacking Shank postsynaptic scaffolds as an animal model of autism Sheng, Morgan Q4.S.B Massachusetts Institute of Technology
Using zebrafish and chemical screening to define function of autism genes Sive, Hazel Q4.S.B Whitehead Institute for Biomedical Research
Function and dysfunction of neuroligins Sudhof, Thomas Q4.S.B Stanford University
Neural and cognitive mechanisms of autism Sur, Mriganka Q4.S.B Massachusetts Institute of Technology
Characterization of the transcriptome in an emerging model for social behavior Thomas, James Q4.S.B Emory University
Integrated approach to the neurobiology of autism spectrum disorders Vaccarino, Flora Q4.S.B Yale University
Cellular and genetic correlates of increased head size in autism spectrum disorder Vaccarino, Flora Q4.S.B Yale University
The role of SHANK3 in the etiology of autism spectrum disorder Bangash, M. Ali Q4.S.B Johns Hopkins University
Mouse genetic model of a dysregulated serotonin transporter variant associated with autism Veenstra-Vanderweele, Jeremy Q4.S.B Vanderbilt University
Murine genetic models of autism Veenstra-Vanderweele, Jeremy Q4.S.B Vanderbilt University
Cntnap2 in a behavioral model of autism White, Stephanie Q4.S.B University of California, Los Angeles
Identifying genetic modifiers of rett syndrome in the mouse Buchovecky, Christine Q4.S.B Baylor College of Medicine
Dynamic regulation of Shank3 and ASD Worley, Paul Q4.S.B Johns Hopkins University
Basal ganglia circuitry and molecules in pathogenesis of motor stereotypy Yang, Xiangdong Q4.S.B University of California, Los Angeles
Genomic resources for identifying genes regulating social behavior Young, Larry Q4.S.B Emory University
Vasopressin receptors and social attachment Young, Larry Q4.S.B Emory University
Neural mechanisms of social cognition and bonding Young, Larry Q4.S.B Emory University