Subcategory Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Model Systems/Therapeutic Targets$24,115,793.04
Fiscal Year: 2010
  

Download 2010 Model Systems/Therapeutic Targets projects (EXCEL)
Animal models mimicking behaviors of ASD and those that are being used to develop or test new drug treatments, as well as cell lines used to discover new drug targets or to screen potential drug candidates, are included in this subcategory.
Graph: The subcategories for Question 4 illustrate the many approaches to treatments and interventions supported by autism research funders. The largest amount of funding supported projects to develop Model systems and therapeutic targets (35%), followed by research on Behavioral interventions (29%). Medical/Pharmacologic interventions received 16% of funding, classroom-based interventions (Educational) received 10% of funding, and Technology-based interventions and supports received 7% of funding. The subcategories with the smallest amounts of funding included Occupational, physical, and sensory-based (2%) and Complementary, dietary, and alternative (1%).
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Investigation of the role of MET kinase in autism Dawson, Ted Q4.S.B Johns Hopkins University School of Medicine
Control of synaptic protein synthesis in the pathogenesis and therapy of autism Kelleher, Raymond Q4.S.B Massachusetts General Hospital
Development of a high-content neuronal assay to screen therapeutics for the treatment of cognitive dysfunction in autism spectrum disorders Bear, Mark Q4.S.B Massachusetts Institute of Technology
Neurobiology of mouse models for human chr 16p11.2 microdeletion and fragile X Bear, Mark Q4.S.B Massachusetts Institute of Technology
Mice lacking Shank postsynaptic scaffolds as an animal model of autism Sheng, Morgan Q4.S.B Massachusetts Institute of Technology
Neural and cognitive mechanisms of autism Sur, Mriganka Q4.S.B Massachusetts Institute of Technology
Dissecting the circuitry basis of autistic-like behaviors in mice Feng, Guoping Q4.S.B Massachusetts Institute of Technology
Synaptic and circuitry mechanisms of repetitive behaviors in autism Feng, Guoping Q4.S.B Massachusetts Institute of Technology
Using Drosophila to model the synaptic function of the autism-linked NHE9 Littleton, J. Troy Q4.S.B Massachusetts Institute of Technology
Genetic models of serotonin transporter regulation linked to mental disorders Ramamoorthy, Sammanda Q4.S.B Medical University of South Carolina
The role of SHANK3 in autism spectrum disorders Buxbaum, Joseph Q4.S.B Mount Sinai School of Medicine
A preclinical model for determining the role of AVPR1A in autism spectrum disorders Charles, Rhonda Q4.S.B Mount Sinai School of Medicine
Animal models of neuropsychiatric disorders Crawley, Jacqueline Q4.S.B National Institutes of Health
Regulation of gene expression in the brain Young, Walter Q4.S.B National Institutes of Health
Synaptic plasticity, memory and social behavior Chevere-Torres, Itzamarie Q4.S.B New York University
Methods for production of ICSI and SCNT derived macaque stem cells Schatten, Gerald Q4.S.B Southwest Foundation For Biomedical Research
Optimization of methods for production of both ICSI- and SCNT derived baboon embryonic stem cells Schatten, Gerald Q4.S.B Southwest Foundation For Biomedical Research
Micro-RNA regulation in pluripotent stem cells Schatten, Gerald Q4.S.B Southwest Foundation For Biomedical Research
Using iPS cells to study genetically defined forms with autism Dolmetsch, Ricardo Q4.S.B Stanford University
Using induced pluripotent stem cells to identify cellular phenotypes of autism Dolmetsch, Ricardo Q4.S.B Stanford University
Exploring the neuronal phenotype of autism spectrum disorders using induced pluripotent stem cells Hallmayer, Joachim; Dolmetsch, Ricardo Q4.S.B Stanford University
Synaptic deficits of iPS cell-derived neurons from patients with autism Mao, Rong Q4.S.B Stanford University
Function and dysfunction of neuroligins Sudhof, Thomas Q4.S.B Stanford University
Identification of autism genes that regulate synaptic Nrx/Nlg signaling complexes Garner, Craig Q4.S.B Stanford University
Role of L-type calcium channels in hippocampal neuronal network activity Owen, Scott Q4.S.B Stanford University