Subcategory Detail
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Office of Autism Research Coordination (OARC) logo

Molecular Pathways$28,759,657.25
Fiscal Year: 2010
  

Download 2010 Molecular Pathways projects (EXCEL)
This subcategory includes studies on specific molecules and proteins (other than the immune and metabolic systems) that may be involved in the development of ASD and related genetic disorders (e.g., fragile X syndrome and Rett syndrome). Many of these projects use animal and cellular models to explore the biological effects of specific candidate genes and to identify common molecular pathways, including alterations in synaptic functioning and intracellular signaling cascades.
Graph: Question 2 encompassed a broad range of biological research, resulting in the need to create a larger number of subcategories to adequately describe the breadth of research than was required for other Strategic Plan Questions. The subcategory with the largest portion of funding was Molecular pathways (32%), followed by Neural systems and Subgroups/Biosignatures, which each received less than half the funding of Molecular pathways (15% and 14%, respectively). Projects related to Developmental trajectory were supported by 11% of 2010 ASD research funding, and research on Sensory and motor function received 7%. Studies on Immune/Metabolic pathways (6%), Co-occurring conditions (5%), Cognitive studies (5%), and Computational science (4%) round out the types of research in Question 2.
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Identification of candidate genes at the synapse in autism spectrum disorders Gupta, Abha Q2.Other Yale University
Imaging PTEN-induced changes in adult cortical structure and function in vivo Trachtenberg, Joshua Q2.Other University of California, Los Angeles
Imaging signal transduction in single dendritic spines Yasuda, Ryohei Q2.Other Duke University
Imaging synaptic neurexin-neuroligin complexes by proximity biotinylation: Applications to the molecular pathogenesis of autism Thyagarajan, Amar Q2.Other Massachusetts Institute of Technology
Investigation of postnatal drug intervention's potential in rescuing the symptoms of fragile X syndrome in adult mice Sidorov, Michael Q2.S.D Massachusetts Institute of Technology
Investigation of sex differences associated with autism candidate gene, CYFIP1 Werling, Donna Q2.S.B University of California, Los Angeles
In-vivo imaging of neuronal structure and function in a reversible mouse model for autism. Ash, Ryan Q2.S.D Baylor College of Medicine
Kinetics of drug macromolecule complex formation Taylor, Palmer Q2.Other University of California, San Diego
L-type calcium channel regulation of neuronal differentiation Panagiotakos, Georgia Q2.S.D Stanford University
MeCP2 modulation of BDNF signaling: Shared mechanisms of Rett and autism Pozzo-Miller, Lucas Q2.S.D University of Alabama at Birmingham
Met signaling in neural development and circuitry formation Qiu, Shenfeng Q2.Other University of Southern California
MicroRNAs in synaptic plasticity and behaviors relevant to autism Kelleher, Raymond Q2.S.D Massachusetts General Hospital
Modulation of fxr1 splicing as a treatment strategy for autism in fragile X syndrome Lin, Michael Q2.S.D Stanford University
Molecular basis of autism associated with human adenylosuccinate lyase gene defects Colman, Roberta Q2.S.D University of Delaware
Molecular mechanisms regulating synaptic strength DiAntonio, Aaron Q2.Other Washington University
Morphogenesis and function of the cerebral cortex Vaccarino, Flora Q2.Other Yale University
Mouse models of human autism spectrum disorders: Gene targeting in specific brain regions Parada, Luis Q2.S.D University of Texas Southwestern Medical Center
Neural circuit deficits in animal models of Rett syndrome Xiong, Qiaojie Q2.S.D Cold Spring Harbor Laboratory
Neurexin-neuroligin trans-synaptic interaction in learning and memory Kandel, Eric Q2.Other Columbia University
Neurexin-neuroligin trans-synaptic interaction in learning and memory Kandel, Eric Q2.Other Columbia University
Neuroligin regulation of central GABAergic synapses Fu, Zhanyan Q2.Other Duke University
Neuroligins and neurexins as autism candidate genes: Study of their association in synaptic connectivity Comoletti, Davide Q2.Other University of California, San Diego
Neuronal activity-dependent regulation of MeCP2 Greenberg, Michael Q2.S.D Harvard Medical School
Neuronal activity-dependent regulation of MeCP2 (supplement) Greenberg, Michael Q2.S.D Harvard Medical School
New approaches to local translation: SpaceSTAMP of proteins synthesized in axons Segal, Rosalind Q2.S.D Dana-Farber Cancer Institute