Subcategory Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Model Systems/Therapeutic Targets$24,115,793.04
Fiscal Year: 2010
  

Download 2010 Model Systems/Therapeutic Targets projects (EXCEL)
Animal models mimicking behaviors of ASD and those that are being used to develop or test new drug treatments, as well as cell lines used to discover new drug targets or to screen potential drug candidates, are included in this subcategory.
Graph: The subcategories for Question 4 illustrate the many approaches to treatments and interventions supported by autism research funders. The largest amount of funding supported projects to develop Model systems and therapeutic targets (35%), followed by research on Behavioral interventions (29%). Medical/Pharmacologic interventions received 16% of funding, classroom-based interventions (Educational) received 10% of funding, and Technology-based interventions and supports received 7% of funding. The subcategories with the smallest amounts of funding included Occupational, physical, and sensory-based (2%) and Complementary, dietary, and alternative (1%).
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Synaptic deficits of iPS cell-derived neurons from patients with autism Mao, Rong Q4.S.B Stanford University
NrCAM, a candidate susceptibility gene for visual processing deficits in autism Maness, Patricia Q4.S.B University of North Carolina at Chapel Hill
Neuropharmacology of motivation and reinforcement in mouse models of autistic spectrum disorders Malanga, C.J. Q4.S.B University of North Carolina School of Medicine
Evaluation of altered fatty acid metabolism via gas chromatography/mass spectroscopy and time-of-flight secondary ion mass spectroscopy imaging in the propionic acid rat model of autism spectrum disorders MacFabe, Derrick Q4.S.B University of Western Ontario
Autism iPSCs for studying function and dysfunction in human neural development Loring, Jeanne Q4.S.B The Scripps Research Institute
Insight into MeCP2 function raises therapeutic possibilities for Rett syndrome Lomvardas, Stavros Q4.S.B University of California, San Francisco
Using Drosophila to model the synaptic function of the autism-linked NHE9 Littleton, J. Troy Q4.S.B Massachusetts Institute of Technology
Interaction between MEF2 and MECP2 in the pathogenesis of autism spectrum disorders - 1 Lipton, Stuart Q4.S.B Burnham Institute
Serotonin, corpus callosum, and autism Lin, Rick Q4.S.B University of Mississippi Medical Center
The genetics of restricted, repetitive behavior: An inbred mouse model Lewis, Mark Q4.S.B University of Florida
Behavioral and physiological consequences of disrupted Met signaling Levitt, Pat Q4.S.B University of Southern California
Shank3 mutant characterization in vivo Kouser, Mehreen Q4.S.B University of Texas Southwestern Medical Center
Animal model of speech sound processing in autism Kilgard, Michael Q4.S.B University of Texas at Dallas
Control of synaptic protein synthesis in the pathogenesis and therapy of autism Kelleher, Raymond Q4.S.B Massachusetts General Hospital
Investigating the effects of chromosome 22q11.2 deletions Karayiorgou, Maria Q4.S.B Columbia University
Functional study of synaptic scaffold protein SHANK3 and autism mouse model Jiang, Yong-Hui Q4.S.B Duke University
Preclinical testing of novel oxytocin receptor activators in models of autism phenotypes Jarstfer, Michael Q4.S.B University of North Carolina at Chapel Hill
Neurogenomics in a model for procedural learning Hilliard, Austin Q4.S.B University of California, Los Angeles
High content screens of neuronal development for autism research Halpain, Shelley Q4.S.B University of California, San Diego
Exploring the neuronal phenotype of autism spectrum disorders using induced pluripotent stem cells Hallmayer, Joachim; Dolmetsch, Ricardo Q4.S.B Stanford University
Genomic imbalances at the 22q11 locus and predisposition to autism Gogos, Joseph Q4.S.B Columbia University
Identification of autism genes that regulate synaptic Nrx/Nlg signaling complexes Garner, Craig Q4.S.B Stanford University
Deriving neuroprogenitor cells from peripheral blood of individuals with autism Fujinami, Robert Q4.S.B University of Utah
Functional genomic dissection of language-related disorders Fisher, Simon Q4.S.B University of Oxford
Dissecting the circuitry basis of autistic-like behaviors in mice Feng, Guoping Q4.S.B Massachusetts Institute of Technology