Subcategory Detail
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Office of Autism Research Coordination (OARC) logo

Molecular Pathways$28,759,657.25
Fiscal Year: 2010
  

Download 2010 Molecular Pathways projects (EXCEL)
This subcategory includes studies on specific molecules and proteins (other than the immune and metabolic systems) that may be involved in the development of ASD and related genetic disorders (e.g., fragile X syndrome and Rett syndrome). Many of these projects use animal and cellular models to explore the biological effects of specific candidate genes and to identify common molecular pathways, including alterations in synaptic functioning and intracellular signaling cascades.
Graph: Question 2 encompassed a broad range of biological research, resulting in the need to create a larger number of subcategories to adequately describe the breadth of research than was required for other Strategic Plan Questions. The subcategory with the largest portion of funding was Molecular pathways (32%), followed by Neural systems and Subgroups/Biosignatures, which each received less than half the funding of Molecular pathways (15% and 14%, respectively). Projects related to Developmental trajectory were supported by 11% of 2010 ASD research funding, and research on Sensory and motor function received 7%. Studies on Immune/Metabolic pathways (6%), Co-occurring conditions (5%), Cognitive studies (5%), and Computational science (4%) round out the types of research in Question 2.
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Modulation of fxr1 splicing as a treatment strategy for autism in fragile X syndrome Lin, Michael Q2.S.D Stanford University
L-type calcium channel regulation of neuronal differentiation Panagiotakos, Georgia Q2.S.D Stanford University
Probing a monogenic form of autism from molecules to behavior Tsien, Richard Q2.S.D Stanford University
Augmentation of the cholinergic system in fragile X syndrome: A double-blind placebo study Reiss, Allan Q2.S.D Stanford University
A systematic test of the relation of ASD heterogeneity to synaptic function Sudhof, Thomas; Malenka, Robert Q2.Other Stanford University
Regulation of activity-dependent ProSAP2 synaptic dynamics Rowan, Magali Q2.Other Stanford University
Function and dysfunction of neuroligins in synaptic circuits Sudhof, Thomas Q2.Other Stanford University
Function of neurexins Sudhof, Thomas Q2.Other Stanford University
Synaptic analysis of neuroligin1 function Fuccillo, Marc Q2.Other Stanford University
Regulation of 22q11 genes in embryonic and adult forebrain Lamantia, Anthony Q2.S.D The George Washington University
Glial control of neuronal receptive ending morphology Shaham, Shai Q2.Other The Rockefeller University
Defining cells and circuits affected in autism spectrum disorders Heintz, Nathaniel Q2.Other The Rockefeller University
Cell adhesion molecules in CNS development Mueller, Ulrich Q2.Other The Scripps Research Institute
Genetic studies of autism-related Drosophila neurexin and neuroligin Bhat, Manzoor Q2.Other The University of North Carolina at Chapel Hill
Angelman syndrome (AS) Percy, Alan Q2.S.D University of Alabama at Birmingham
MeCP2 modulation of BDNF signaling: Shared mechanisms of Rett and autism Pozzo-Miller, Lucas Q2.S.D University of Alabama at Birmingham
The role of MeCP2 in Rett syndrome LaSalle, Janine Q2.S.D University of California, Davis
BDNF and the restoration of spine plasticity with autism spectrum disorders Gall, Christine Q2.S.D University of California, Irvine
Investigation of sex differences associated with autism candidate gene, CYFIP1 Werling, Donna Q2.S.B University of California, Los Angeles
TrkB agonist(s), a potential therapy for autism spectrum disorders Sun, Yi Q2.S.D University of California, Los Angeles
Imaging PTEN-induced changes in adult cortical structure and function in vivo Trachtenberg, Joshua Q2.Other University of California, Los Angeles
Role of autism-susceptibility gene, CNTNAP2, in neural circuitry for vocal communication White, Stephanie Q2.Other University of California, Los Angeles
Functional analysis of neurexin IV in Drosophila Zipursky, Larry Q2.Other University of California, Los Angeles
The role of FOX-1 in neurodevelopment and autistic spectrum disorder Fogel, Brent Q2.Other University of California, Los Angeles
The role of the autism-associated gene tuberous sclerosis complex 2 (TSC2) in presynaptic development Williams, Megan Q2.S.D University of California, San Diego