Subcategory Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Model Systems/Therapeutic Targets$24,115,793.04
Fiscal Year: 2010
  

Download 2010 Model Systems/Therapeutic Targets projects (EXCEL)
Animal models mimicking behaviors of ASD and those that are being used to develop or test new drug treatments, as well as cell lines used to discover new drug targets or to screen potential drug candidates, are included in this subcategory.
Graph: The subcategories for Question 4 illustrate the many approaches to treatments and interventions supported by autism research funders. The largest amount of funding supported projects to develop Model systems and therapeutic targets (35%), followed by research on Behavioral interventions (29%). Medical/Pharmacologic interventions received 16% of funding, classroom-based interventions (Educational) received 10% of funding, and Technology-based interventions and supports received 7% of funding. The subcategories with the smallest amounts of funding included Occupational, physical, and sensory-based (2%) and Complementary, dietary, and alternative (1%).
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Patient iPS cells with copy number variations to model neuropsychiatric disorders Ellis, James Q4.S.B The Hospital for Sick Children
Serotonin, autism, and investigating cell types for CNS disorders Dougherty, Joseph Q4.S.B The Rockefeller University
Autism iPSCs for studying function and dysfunction in human neural development Loring, Jeanne Q4.S.B The Scripps Research Institute
Design & synthesis of novel CNS-active oxytocin and vasopressin receptor ligands Roberts, Edward Q4.Other The Scripps Research Institute
Small-molecule compounds for treating autism spectrum disorders Philpot, Ben Q4.S.B The University of North Carolina at Chapel Hill
Novel, subtype selective potentiators of nicotinic acetycholine receptors Schulte, Marvin Q4.Other University of Alaska Fairbanks
A novel cell-based assay for autism research and drug discovery Restifo, Linda Q4.S.B University of Arizona
Cntnap2 in a behavioral model of autism White, Stephanie Q4.S.B University of California, Los Angeles
Basal ganglia circuitry and molecules in pathogenesis of motor stereotypy Yang, Xiangdong Q4.S.B University of California, Los Angeles
Neurogenomics in a model for procedural learning Hilliard, Austin Q4.S.B University of California, Los Angeles
High content screens of neuronal development for autism research Halpain, Shelley Q4.S.B University of California, San Diego
Insight into MeCP2 function raises therapeutic possibilities for Rett syndrome Lomvardas, Stavros Q4.S.B University of California, San Francisco
Dissecting the neural control of social attachment Shah, Nirao Q4.S.B University of California, San Francisco
Role of a novel Wnt pathway in autism spectrum disorders Reichardt, Louis Q4.S.B University of California, San Francisco
The genetics of restricted, repetitive behavior: An inbred mouse model Lewis, Mark Q4.S.B University of Florida
The genetic control of social behavior in the mouse Blanchard, Robert Q4.S.B University of Hawai'i at Manoa
A mouse knock-in model for ENGRAILED 2 autism susceptibility Millonig, James Q4.S.B University of Medicine & Dentistry of New Jersey
Serotonin, corpus callosum, and autism Lin, Rick Q4.S.B University of Mississippi Medical Center
Preclinical testing of novel oxytocin receptor activators in models of autism phenotypes Pedersen, Cort Q4.S.B University of North Carolina at Chapel Hill
Novel strategies to manipulate Ube3a expression for the treatment of autism and Angelman syndrome Roth, Bryan Q4.S.B University of North Carolina at Chapel Hill
Preclinical testing of novel oxytocin receptor activators in models of autism phenotypes Jarstfer, Michael Q4.S.B University of North Carolina at Chapel Hill
NrCAM, a candidate susceptibility gene for visual processing deficits in autism Maness, Patricia Q4.S.B University of North Carolina at Chapel Hill
Preclinical testing of novel oxytocin receptor activators in models of autism phenotypes Moy, Sheryl Q4.S.B University of North Carolina at Chapel Hill
Characterization of a novel mouse model of restricted repetitive behaviors Moy, Sheryl Q4.S.B University of North Carolina at Chapel Hill
Neuropharmacology of motivation and reinforcement in mouse models of autistic spectrum disorders Malanga, C.J. Q4.S.B University of North Carolina School of Medicine