Subcategory Detail
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Molecular Pathways$28,759,657.25
Fiscal Year: 2010
  

Download 2010 Molecular Pathways projects (EXCEL)
This subcategory includes studies on specific molecules and proteins (other than the immune and metabolic systems) that may be involved in the development of ASD and related genetic disorders (e.g., fragile X syndrome and Rett syndrome). Many of these projects use animal and cellular models to explore the biological effects of specific candidate genes and to identify common molecular pathways, including alterations in synaptic functioning and intracellular signaling cascades.
Graph: Question 2 encompassed a broad range of biological research, resulting in the need to create a larger number of subcategories to adequately describe the breadth of research than was required for other Strategic Plan Questions. The subcategory with the largest portion of funding was Molecular pathways (32%), followed by Neural systems and Subgroups/Biosignatures, which each received less than half the funding of Molecular pathways (15% and 14%, respectively). Projects related to Developmental trajectory were supported by 11% of 2010 ASD research funding, and research on Sensory and motor function received 7%. Studies on Immune/Metabolic pathways (6%), Co-occurring conditions (5%), Cognitive studies (5%), and Computational science (4%) round out the types of research in Question 2.
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Neurexin-neuroligin trans-synaptic interaction in learning and memory Kandel, Eric Q2.Other Columbia University
Neurexin-neuroligin trans-synaptic interaction in learning and memory Kandel, Eric Q2.Other Columbia University
Retrograde synaptic signaling by Neurexin and Neuroligin in C. elegans Kaplan, Joshua Q2.Other Massachusetts General Hospital
MicroRNAs in synaptic plasticity and behaviors relevant to autism Kelleher, Raymond Q2.S.D Massachusetts General Hospital
Developing novel automated apparatus for studying battery of social behaviors in mutant mouse models for autism Kimchi, Tali Q2.Other Weizmann Institute of Science
Translation regulation in hippocampal LTP and LTD Klann, Eric Q2.S.D New York University
Excessive cap-dependent translation as a molecular mechanism underlying ASD Klann, Eric Q2.Other New York University
The mechanism and significance of Evf ncRNA regulation of the DLX genes Kohtz, Jhumku Q2.S.D University of Washington
The mechanism and significance of Evf ncRNA regulation of the DLX genes Kohtz, Jhumku Q2.Other Children's Memorial Hospital, Chicago
Role of GluK6 in cerebella circuitry development Kubera, Cathryn Q2.Other Yale University
Regulation of 22q11 genes in embryonic and adult forebrain Lamantia, Anthony Q2.S.D The George Washington University
Regulation of 22q11 genes in embryonic and adult forebrain Lamantia, Anthony Q2.S.D University of North Carolina at Chapel Hill
The role of MeCP2 in Rett syndrome LaSalle, Janine Q2.S.D University of California, Davis
Function and structure adaptations in forebrain development Levitt, Pat Q2.Other University of Southern California
Modulation of fxr1 splicing as a treatment strategy for autism in fragile X syndrome Lin, Michael Q2.S.D Stanford University
Ube3a requirements for structural plasticity of synapses McCoy, Portia Q2.Other Univ of North Carolina
Cell adhesion molecules in CNS development Mueller, Ulrich Q2.Other The Scripps Research Institute
Role of intracellular mGluR5 in fragile X syndrome and autism O'Malley, Karen Q2.S.D Washington University in St. Louis
Roles of Wnt signaling/scaffolding molecules in autism Okerlund, Nathan Q2.Other University of California, San Francisco
L-type calcium channel regulation of neuronal differentiation Panagiotakos, Georgia Q2.S.D Stanford University
Mouse models of human autism spectrum disorders: Gene targeting in specific brain regions Parada, Luis Q2.S.D University of Texas Southwestern Medical Center
Elucidating the function of class 4 semaphorins in GABAergic synapse formation Paradis, Suzanne Q2.Other Brandeis University
Glutamate receptor desensitization and its modulation Partin, Kathryn Q2.Other Colorado State University
Angelman syndrome (AS) Percy, Alan Q2.S.D University of Alabama at Birmingham
MeCP2 modulation of BDNF signaling: Shared mechanisms of Rett and autism Pozzo-Miller, Lucas Q2.S.D University of Alabama at Birmingham